Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1820331..1821166 | Replicon | chromosome |
| Accession | NZ_CP084900 | ||
| Organism | Escherichia coli strain EC20 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | LHL15_RS08575 | Protein ID | WP_064221650.1 |
| Coordinates | 1820331..1820708 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | LHL15_RS08580 | Protein ID | WP_001295723.1 |
| Coordinates | 1820798..1821166 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHL15_RS08540 (1815851) | 1815851..1816324 | + | 474 | WP_001105407.1 | DNA gyrase inhibitor SbmC | - |
| LHL15_RS08545 (1816522) | 1816522..1817580 | + | 1059 | WP_001200895.1 | FUSC family protein | - |
| LHL15_RS08550 (1817752) | 1817752..1818081 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| LHL15_RS08555 (1818182) | 1818182..1818547 | - | 366 | WP_001280454.1 | EutP/PduV family microcompartment system protein | - |
| LHL15_RS08560 (1818818) | 1818818..1819207 | - | 390 | WP_077875581.1 | transposase | - |
| LHL15_RS08565 (1820005) | 1820005..1820085 | - | 81 | Protein_1672 | hypothetical protein | - |
| LHL15_RS08570 (1820185) | 1820185..1820334 | - | 150 | Protein_1673 | DUF5983 family protein | - |
| LHL15_RS08575 (1820331) | 1820331..1820708 | - | 378 | WP_064221650.1 | TA system toxin CbtA family protein | Toxin |
| LHL15_RS08580 (1820798) | 1820798..1821166 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LHL15_RS08585 (1821216) | 1821216..1821353 | - | 138 | WP_168787260.1 | hypothetical protein | - |
| LHL15_RS08590 (1821534) | 1821534..1823075 | + | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
| LHL15_RS08595 (1823090) | 1823090..1823836 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| LHL15_RS08600 (1823894) | 1823894..1824136 | - | 243 | WP_049067502.1 | DUF987 domain-containing protein | - |
| LHL15_RS08605 (1824199) | 1824199..1824675 | - | 477 | WP_001186775.1 | RadC family protein | - |
| LHL15_RS08610 (1824691) | 1824691..1825176 | - | 486 | WP_000849588.1 | antirestriction protein | - |
| LHL15_RS08615 (1825231) | 1825231..1826049 | - | 819 | WP_226762398.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14150.14 Da Isoelectric Point: 7.3249
>T220118 WP_064221650.1 NZ_CP084900:c1820708-1820331 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTQLARLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTQLARLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T220118 NZ_CP116931:c3861209-3860811 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT220118 WP_001295723.1 NZ_CP084900:c1821166-1820798 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT220118 NZ_CP116931:c3861505-3861212 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|