Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 220290..220926 Replicon chromosome
Accession NC_009328
Organism Geobacillus thermodenitrificans NG80-2

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GTNG_RS01210 Protein ID WP_003253417.1
Coordinates 220576..220926 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0Q1ENP8
Locus tag GTNG_RS01205 Protein ID WP_008881474.1
Coordinates 220290..220571 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTNG_RS01185 216473..217090 - 618 WP_011886667.1 rhomboid family intramembrane serine protease -
GTNG_RS01190 217231..217620 + 390 WP_008881477.1 holo-ACP synthase -
GTNG_RS01195 217700..218713 + 1014 WP_011886668.1 outer membrane lipoprotein carrier protein LolA -
GTNG_RS01200 219008..220162 + 1155 WP_008881475.1 alanine racemase -
GTNG_RS01205 220290..220571 + 282 WP_008881474.1 hypothetical protein Antitoxin
GTNG_RS01210 220576..220926 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GTNG_RS01215 221587..223752 + 2166 WP_011886670.1 RNA-binding transcriptional accessory protein -
GTNG_RS18550 223769..223882 - 114 WP_087959817.1 cortex morphogenetic protein CmpA -
GTNG_RS01220 223973..224461 + 489 WP_008881471.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T22011 WP_003253417.1 NC_009328:220576-220926 [Geobacillus thermodenitrificans NG80-2]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T22011 NC_009328:220576-220926 [Geobacillus thermodenitrificans NG80-2]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTCGTTGGCTCAGAGCAGGGCGGCGTACGCCCCGT
GTTGGTGATCCAAAACGATATCGGTAATCGCTTTAGTCCGACGGTGATTGTGGCGGCGATTACGGCGCAAATCCAGAAGG
CGAAACTGCCGACGCATGTTGAAATCGATGCAAAACGCTACGGGTTTGAGCGCGATTCCGTCATTTTGCTTGAGCAAATT
CGTACGATTGATAAGCAACGGTTGACCGATAAAATTACCCACTTGGACGATGAAATGATGGATAAAGTTGATGAGGCGCT
GCAAATCAGCTTAGGATTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10627.09 Da        Isoelectric Point: 7.2027

>AT22011 WP_008881474.1 NC_009328:220290-220571 [Geobacillus thermodenitrificans NG80-2]
VSESGATTEIVVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT22011 NC_009328:220290-220571 [Geobacillus thermodenitrificans NG80-2]
GTGTCGGAATCTGGCGCAACAACGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACGGAACTGGACGGGCTTGTCAA
ACAGGAGAACGGCAATCGAAATGAACTCATTTATCAAGCGACGAAAATGTATATTCGTGAACGGAAAAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCCAAAATCAATTTATCTATTGCTTCTGAAGCGTTTCATGCCGAATAT
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1ENP8

References