219978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4542769..4543583 Replicon chromosome
Accession NZ_CP084896
Organism Escherichia coli strain g62

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag LHV62_RS22075 Protein ID WP_001054376.1
Coordinates 4543326..4543583 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag LHV62_RS22070 Protein ID WP_001309181.1
Coordinates 4542769..4543314 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV62_RS22040 (4538460) 4538460..4539773 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
LHV62_RS22045 (4539785) 4539785..4540063 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
LHV62_RS22050 (4540060) 4540060..4541181 - 1122 WP_000010829.1 M42 family metallopeptidase -
LHV62_RS22055 (4541426) 4541426..4541542 - 117 Protein_4293 VOC family protein -
LHV62_RS22060 (4541580) 4541580..4541798 - 219 Protein_4294 hypothetical protein -
LHV62_RS22065 (4541967) 4541967..4542713 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
LHV62_RS22070 (4542769) 4542769..4543314 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
LHV62_RS22075 (4543326) 4543326..4543583 - 258 WP_001054376.1 YjhX family toxin Toxin
LHV62_RS22080 (4544074) 4544074..4544205 - 132 WP_001309182.1 hypothetical protein -
LHV62_RS22085 (4544321) 4544321..4545561 + 1241 Protein_4299 helicase YjhR -
LHV62_RS22090 (4545829) 4545829..4546034 - 206 Protein_4300 HNH endonuclease -
LHV62_RS22095 (4546144) 4546144..4547124 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
LHV62_RS22100 (4547189) 4547189..4548295 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T219978 WP_001054376.1 NZ_CP084896:c4543583-4543326 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T219978 NZ_CP116909:747423-747674 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT219978 WP_001309181.1 NZ_CP084896:c4543314-4542769 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT219978 NZ_CP116909:747664-747837 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References