Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1511610..1512248 Replicon chromosome
Accession NZ_CP084896
Organism Escherichia coli strain g62

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LHV62_RS07435 Protein ID WP_000813794.1
Coordinates 1511610..1511786 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LHV62_RS07440 Protein ID WP_001270286.1
Coordinates 1511832..1512248 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV62_RS07415 (1507229) 1507229..1508443 - 1215 WP_001326689.1 BenE family transporter YdcO -
LHV62_RS07420 (1508496) 1508496..1509032 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
LHV62_RS07425 (1509105) 1509105..1511066 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LHV62_RS07430 (1511158) 1511158..1511388 - 231 WP_000494244.1 YncJ family protein -
LHV62_RS07435 (1511610) 1511610..1511786 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LHV62_RS07440 (1511832) 1511832..1512248 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LHV62_RS07445 (1512327) 1512327..1513733 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
LHV62_RS07450 (1513978) 1513978..1515123 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
LHV62_RS07455 (1515141) 1515141..1516154 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LHV62_RS07460 (1516155) 1516155..1517096 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T219954 WP_000813794.1 NZ_CP084896:1511610-1511786 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T219954 NZ_CP116903:746640-747125 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT219954 WP_001270286.1 NZ_CP084896:1511832-1512248 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT219954 NZ_CP116903:746350-746643 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References