Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 3046492..3047146 | Replicon | chromosome |
Accession | NZ_CP084894 | ||
Organism | Escherichia coli strain g83 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | S1EEB2 |
Locus tag | LHV61_RS14875 | Protein ID | WP_000244777.1 |
Coordinates | 3046492..3046899 (-) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S1PPB1 |
Locus tag | LHV61_RS14880 | Protein ID | WP_000354046.1 |
Coordinates | 3046880..3047146 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LHV61_RS14855 (3042449) | 3042449..3044182 | - | 1734 | WP_000813200.1 | single-stranded-DNA-specific exonuclease RecJ | - |
LHV61_RS14860 (3044188) | 3044188..3044898 | - | 711 | WP_000715214.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LHV61_RS14865 (3044923) | 3044923..3045819 | - | 897 | WP_000806638.1 | site-specific tyrosine recombinase XerD | - |
LHV61_RS14870 (3045931) | 3045931..3046452 | + | 522 | WP_001055874.1 | flavodoxin FldB | - |
LHV61_RS14875 (3046492) | 3046492..3046899 | - | 408 | WP_000244777.1 | protein YgfX | Toxin |
LHV61_RS14880 (3046880) | 3046880..3047146 | - | 267 | WP_000354046.1 | FAD assembly factor SdhE | Antitoxin |
LHV61_RS14885 (3047389) | 3047389..3048369 | + | 981 | WP_000886062.1 | tRNA-modifying protein YgfZ | - |
LHV61_RS14890 (3048565) | 3048565..3049224 | - | 660 | WP_000250274.1 | hemolysin III family protein | - |
LHV61_RS14895 (3049388) | 3049388..3049699 | - | 312 | WP_001182957.1 | N(4)-acetylcytidine aminohydrolase | - |
LHV61_RS14900 (3049744) | 3049744..3051177 | + | 1434 | WP_001336277.1 | 6-phospho-beta-glucosidase BglA | - |
LHV61_RS14905 (3051234) | 3051234..3051977 | - | 744 | WP_000951964.1 | SDR family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 16031.96 Da Isoelectric Point: 11.5202
>T219884 WP_000244777.1 NZ_CP084894:c3046899-3046492 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR
Download Length: 408 bp
>T219884 NZ_CP116775:5960662-5961522 [Pseudomonas sp. 273]
ATGACGGCGATGACCGCGGCGGCCGCCTGGCAGGCCGACCTGGAACGCGACTTCCCGCAGCGCCTGGTGCGCCACGGCGA
AACCGTCGCCGCTGTGCGCGAGGCCGGCGCAACCGACGCACCGGCGCTGGTGCTGCTGCACGGCATCGGCTCCGGCGCGG
CCTCCTGGCTGCCGCTGGCGCAACGCCTGAAGGACCGCGCGCGGATCATCGCCTGGGACGCCCCCGGCTACGGCGAGTCG
ACGCCGCTGGCCGAAGCCGCGCCGCGGGCGGAAGCCTACATGGGCCGCCTGCGCGAACTGCTGGATGCGCTGGGCGTGCG
GCGTTGCCTGCTGCTCGGCCATTCCCTGGGCGCGATGGCCGCCCTGGCCCTGGCCAATGCCGAGCCGCAGCGCGTGGCCC
GCCTGGTGCTGCTCAGCCCCGCGCGCGGCTACGGCGCACGCCCGGACGAAGGCGAGGCGGTACGCAGCCGGCGCCTCGCC
GGGCTGGCCAGCGAAGGCATCGCCGGCCTCGCCGAGCGCCGTGCGCCGGCCATGCTCGGCGCCAACCCGGACGCCGCGGC
GCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAGGCCCCACGGCTACCGCCAGGCGGTGGAGCTGCTGTGCGGCGACG
ACCTGCTGCGCCTGGGCCGCCCGCCCGTGCCCAGCGAGGTGCTGTGCGGCAGCGAGGACGGCATCACCCCGCCCGCCGCC
TGCCGCGAAGTCGCCGAAGCGCTGGCGGCGCCCTTCCAGCTCGTACCCGGGGCCGGCCACGCCAGCCCCATCGAATGCCC
CGAAGCCCTGGCCGGGCTGCTTGCCCGGCTTATCGAGCACTGCCAAGGACTGAAACCATGA
ATGACGGCGATGACCGCGGCGGCCGCCTGGCAGGCCGACCTGGAACGCGACTTCCCGCAGCGCCTGGTGCGCCACGGCGA
AACCGTCGCCGCTGTGCGCGAGGCCGGCGCAACCGACGCACCGGCGCTGGTGCTGCTGCACGGCATCGGCTCCGGCGCGG
CCTCCTGGCTGCCGCTGGCGCAACGCCTGAAGGACCGCGCGCGGATCATCGCCTGGGACGCCCCCGGCTACGGCGAGTCG
ACGCCGCTGGCCGAAGCCGCGCCGCGGGCGGAAGCCTACATGGGCCGCCTGCGCGAACTGCTGGATGCGCTGGGCGTGCG
GCGTTGCCTGCTGCTCGGCCATTCCCTGGGCGCGATGGCCGCCCTGGCCCTGGCCAATGCCGAGCCGCAGCGCGTGGCCC
GCCTGGTGCTGCTCAGCCCCGCGCGCGGCTACGGCGCACGCCCGGACGAAGGCGAGGCGGTACGCAGCCGGCGCCTCGCC
GGGCTGGCCAGCGAAGGCATCGCCGGCCTCGCCGAGCGCCGTGCGCCGGCCATGCTCGGCGCCAACCCGGACGCCGCGGC
GCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAGGCCCCACGGCTACCGCCAGGCGGTGGAGCTGCTGTGCGGCGACG
ACCTGCTGCGCCTGGGCCGCCCGCCCGTGCCCAGCGAGGTGCTGTGCGGCAGCGAGGACGGCATCACCCCGCCCGCCGCC
TGCCGCGAAGTCGCCGAAGCGCTGGCGGCGCCCTTCCAGCTCGTACCCGGGGCCGGCCACGCCAGCCCCATCGAATGCCC
CGAAGCCCTGGCCGGGCTGCTTGCCCGGCTTATCGAGCACTGCCAAGGACTGAAACCATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10547.12 Da Isoelectric Point: 5.1599
>AT219884 WP_000354046.1 NZ_CP084894:c3047146-3046880 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT219884 NZ_CP116775:5961519-5962340 [Pseudomonas sp. 273]
ATGAGTACCGACACCCTCAACGAACCCCAGGAACGCTACATGGTTCCGGGGCTGGAGCGCGGCCTGACGCTGCTGGGCGA
GTTCACCCGCCACGACCGCACCCTCACCGCCCCGGAGCTGGCGCGCCGCCTGCAGTTGCCGCGCACCACCATCTTCCGCC
TGCTGGCCACCCTCGAGGCCCTGGGCTTCGTCACCCGCAGCGGCAACGAATACCGCCTGGGCATGGCGGTGCTGCGCCTG
GGCTTCGAGTACCTGGCCTCGCTGGAACTCACCGAACTGGGCCAGCCGATCCTGCGGCGCCTGTGCGACGCCATCGGCTA
CTCCTGCAACCTGGTGGTACGCGACGGGCGCAACATCGTCTACGTGGCGAAGATCTCGCCGCCGTCGATCCTCACCAGCG
CGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTCCTGGAGGACCTGGACCTCGCCGCG
CTGCGCGAGCTGTACCCGGAGAAACAGCTGGAACGCTTCTCCGAGGGCACCCCGCGCAACGCCGAGGAACTCTTCGACCT
GGTGCAGAACGACCGCCTGCGCGGCTACGCCCTCAGCGAAGGCTTCTTCGAGGCGAGCATCTCCACCGTCGCCGCGCCGG
TGCGCGACCACACCGGGCGGGTCTGCGCCGCCATGGGCGTGACCATCCCCGCCACGCGCATCGCCGAGCACCTGCTGGAG
CCGCTGGTGCGCCAGGTGCGCAACAGCGCCGAGGAACTCTCCGGCCTGCTCGGGCACATGCCCAACCCCAACGTGCTGTC
GCTGCAGAGGGTCCACCCATGA
ATGAGTACCGACACCCTCAACGAACCCCAGGAACGCTACATGGTTCCGGGGCTGGAGCGCGGCCTGACGCTGCTGGGCGA
GTTCACCCGCCACGACCGCACCCTCACCGCCCCGGAGCTGGCGCGCCGCCTGCAGTTGCCGCGCACCACCATCTTCCGCC
TGCTGGCCACCCTCGAGGCCCTGGGCTTCGTCACCCGCAGCGGCAACGAATACCGCCTGGGCATGGCGGTGCTGCGCCTG
GGCTTCGAGTACCTGGCCTCGCTGGAACTCACCGAACTGGGCCAGCCGATCCTGCGGCGCCTGTGCGACGCCATCGGCTA
CTCCTGCAACCTGGTGGTACGCGACGGGCGCAACATCGTCTACGTGGCGAAGATCTCGCCGCCGTCGATCCTCACCAGCG
CGGTCAACGTCGGCACCCGCCTGCCGGCCCACGCCACGGTGCTGGGGCGCATCCTCCTGGAGGACCTGGACCTCGCCGCG
CTGCGCGAGCTGTACCCGGAGAAACAGCTGGAACGCTTCTCCGAGGGCACCCCGCGCAACGCCGAGGAACTCTTCGACCT
GGTGCAGAACGACCGCCTGCGCGGCTACGCCCTCAGCGAAGGCTTCTTCGAGGCGAGCATCTCCACCGTCGCCGCGCCGG
TGCGCGACCACACCGGGCGGGTCTGCGCCGCCATGGGCGTGACCATCCCCGCCACGCGCATCGCCGAGCACCTGCTGGAG
CCGCTGGTGCGCCAGGTGCGCAACAGCGCCGAGGAACTCTCCGGCCTGCTCGGGCACATGCCCAACCCCAACGTGCTGTC
GCTGCAGAGGGTCCACCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LFV7 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 6B58 | |
PDB | 1X6I | |
PDB | 1X6J | |
PDB | 6C12 | |
AlphaFold DB | A0A7U9QD57 |