Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2082080..2082911 | Replicon | chromosome |
| Accession | NZ_CP084894 | ||
| Organism | Escherichia coli strain g83 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | LHV61_RS10355 | Protein ID | WP_000854814.1 |
| Coordinates | 2082537..2082911 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | P76364 |
| Locus tag | LHV61_RS10350 | Protein ID | WP_001285584.1 |
| Coordinates | 2082080..2082448 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHV61_RS10335 (2079747) | 2079747..2081279 | + | 1533 | WP_001350525.1 | protein YeeR | - |
| LHV61_RS10340 (2081276) | 2081276..2081722 | + | 447 | WP_000187523.1 | RadC family protein | - |
| LHV61_RS10345 (2081785) | 2081785..2082006 | + | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| LHV61_RS10350 (2082080) | 2082080..2082448 | + | 369 | WP_001285584.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| LHV61_RS10355 (2082537) | 2082537..2082911 | + | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| LHV61_RS10360 (2082908) | 2082908..2083102 | + | 195 | WP_000988600.1 | DUF5983 family protein | - |
| LHV61_RS10365 (2083148) | 2083148..2083228 | + | 81 | Protein_2025 | hypothetical protein | - |
| LHV61_RS10370 (2083517) | 2083517..2083645 | - | 129 | Protein_2026 | transposase domain-containing protein | - |
| LHV61_RS10375 (2083765) | 2083765..2083899 | + | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| LHV61_RS10380 (2084000) | 2084000..2084329 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| LHV61_RS10385 (2084501) | 2084501..2085559 | - | 1059 | WP_001200891.1 | FUSC family protein | - |
| LHV61_RS10390 (2085757) | 2085757..2086230 | - | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| LHV61_RS10395 (2086349) | 2086349..2087515 | - | 1167 | WP_000830156.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T219879 WP_000854814.1 NZ_CP084894:2082537-2082911 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T219879 NZ_CP116775:1965340-1965864 [Pseudomonas sp. 273]
ATGATCTCGAAAACGCTCGGCGCCGACGGCGACGAGGCCTTTTACCGAGTCATCGTGCCGGCCTATGCCGGCACGCCCTT
GTCCGGGATGGGAGCGGCGCGCCAAGGAGGGCGGTTCAACCGTCCGGACCAGGAGGCGCTGTACCTGGCGCTGGATGAGT
CGACGGCGTTGGCCGAATACAAGCAGGACAACCCGTGGCTGCGTCCGGGCACGATCTGCACGTTCTTCATCAACGGCCTG
CGCGTCGCTGACTTGAGTGCCGGTTTCGATCCGGATCGCTGGCCGCCGCTCTGGGCTGACTACACGGTGGACTGGCGAGC
GGAGTGGTTCGACAAGTCGGTCGAGCCGCCTACTTGGTACATGGCTGACGATGTGGTTGCCGCTGGGCTGGATGGCATTC
TGTTTCCTTCGCAGGCGAGGCCGGGTGGAACCAACCTAGTGATCTACCACAGCTCGTCCCGGCCTGCGGCGCAACTGCGA
GTCTATGATCCGGACGGAGCCTTGCAGCGCCTGATAAATCGATGA
ATGATCTCGAAAACGCTCGGCGCCGACGGCGACGAGGCCTTTTACCGAGTCATCGTGCCGGCCTATGCCGGCACGCCCTT
GTCCGGGATGGGAGCGGCGCGCCAAGGAGGGCGGTTCAACCGTCCGGACCAGGAGGCGCTGTACCTGGCGCTGGATGAGT
CGACGGCGTTGGCCGAATACAAGCAGGACAACCCGTGGCTGCGTCCGGGCACGATCTGCACGTTCTTCATCAACGGCCTG
CGCGTCGCTGACTTGAGTGCCGGTTTCGATCCGGATCGCTGGCCGCCGCTCTGGGCTGACTACACGGTGGACTGGCGAGC
GGAGTGGTTCGACAAGTCGGTCGAGCCGCCTACTTGGTACATGGCTGACGATGTGGTTGCCGCTGGGCTGGATGGCATTC
TGTTTCCTTCGCAGGCGAGGCCGGGTGGAACCAACCTAGTGATCTACCACAGCTCGTCCCGGCCTGCGGCGCAACTGCGA
GTCTATGATCCGGACGGAGCCTTGCAGCGCCTGATAAATCGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13651.52 Da Isoelectric Point: 5.9541
>AT219879 WP_001285584.1 NZ_CP084894:2082080-2082448 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT219879 NZ_CP116775:1964972-1965343 [Pseudomonas sp. 273]
ATGAATACTGTGCTGCAAGAACCCTTTGTCGAGCGGTTCCGCGAGCCCAACACGCCCTACCTGTCTCCGTCCAAGGTGGG
TGACTTCTTTGGATTTCGGGTCCAGGAGTTGGCCGAGCGTGCGCATGTGCATCGCAATACTCCGACAGCTCGGCCCCAGG
CGCCGCAGTTGCAGAAGTACCTGCAGGACATGGTGCGAGTGCTGGCGGTGGCCACCGAGATGACCGGCGACGTCCATCGG
GCGGTCTTTCTGCTGCGCAATGAACCGCTGCGTGCGTTTGGCTACAAGACCGCGGATACCCTGATCCAGGAAGGTCGCGC
CGATGCGGTCATTGCCTACCTCGAATCCTTTGCCGGTGGTGCGGCCGGATGA
ATGAATACTGTGCTGCAAGAACCCTTTGTCGAGCGGTTCCGCGAGCCCAACACGCCCTACCTGTCTCCGTCCAAGGTGGG
TGACTTCTTTGGATTTCGGGTCCAGGAGTTGGCCGAGCGTGCGCATGTGCATCGCAATACTCCGACAGCTCGGCCCCAGG
CGCCGCAGTTGCAGAAGTACCTGCAGGACATGGTGCGAGTGCTGGCGGTGGCCACCGAGATGACCGGCGACGTCCATCGG
GCGGTCTTTCTGCTGCGCAATGAACCGCTGCGTGCGTTTGGCTACAAGACCGCGGATACCCTGATCCAGGAAGGTCGCGC
CGATGCGGTCATTGCCTACCTCGAATCCTTTGCCGGTGGTGCGGCCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FY50 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M2E8G6 |