Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2172747..2173261 Replicon chromosome
Accession NZ_CP084892
Organism Staphylococcus aureus strain CC1956/ST4614-MSSA

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LB315_RS10855 Protein ID WP_000581792.1
Coordinates 2172747..2172956 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LB315_RS10860 Protein ID WP_000138934.1
Coordinates 2172968..2173261 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB315_RS10835 (2168255) 2168255..2169613 - 1359 WP_229373849.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LB315_RS10840 (2169628) 2169628..2170698 - 1071 WP_221904250.1 D-alanine--D-alanine ligase -
LB315_RS10845 (2171016) 2171016..2172218 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LB315_RS10850 (2172482) 2172482..2172619 - 138 WP_000828354.1 Lmo0850 family protein -
LB315_RS10855 (2172747) 2172747..2172956 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LB315_RS10860 (2172968) 2172968..2173261 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LB315_RS10865 (2173427) 2173427..2174911 + 1485 WP_000571551.1 cardiolipin synthase -
LB315_RS10870 (2174939) 2174939..2175586 + 648 WP_229373850.1 HD domain-containing protein -
LB315_RS10875 (2176458) 2176458..2177330 - 873 WP_229373851.1 membrane protein insertase YidC -
LB315_RS10880 (2177416) 2177416..2178057 - 642 WP_229373852.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T219802 WP_000581792.1 NZ_CP084892:c2172956-2172747 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T219802 NZ_CP116718:3249216-3249497 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT219802 WP_000138934.1 NZ_CP084892:c2173261-2172968 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT219802 NZ_CP116718:3248981-3249226 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References