Detailed information of TA system TA219800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1995742..1996518
• Replicon: chromosome
• Accession: NZ_CP084892
• Organism: Staphylococcus aureus strain CC1956/ST4614-MSSA

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: LB315_RS09855
• Protein ID: WP_000031108.1
• Coordinates: 1995742..1995894 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LB315_RS09860
• Protein ID: WP_001251217.1
• Coordinates: 1995919..1996518 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB315_RS09840 (1991894)	1991894..1992715	+	822	WP_000669377.1	RluA family pseudouridine synthase	-
LB315_RS09845 (1993165)	1993165..1994550	-	1386	WP_000116225.1	class II fumarate hydratase	-
LB315_RS09850 (1994746)	1994746..1995141	-	396	WP_000901023.1	hypothetical protein	-
LB315_RS09855 (1995742)	1995742..1995894	-	153	WP_000031108.1	SAS053 family protein	Toxin
LB315_RS09860 (1995919)	1995919..1996518	-	600	WP_001251217.1	hypothetical protein	Antitoxin
LB315_RS09865 (1996677)	1996677..1997147	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LB315_RS09870 (1997152)	1997152..1998279	-	1128	WP_229373827.1	tRNA epoxyqueuosine(34) reductase QueG	-
LB315_RS09875 (1998430)	1998430..1999152	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LB315_RS09880 (1999145)	1999145..2000602	-	1458	WP_000649902.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T219800 WP_000031108.1 NZ_CP084892:c1995894-1995742 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T219800 NZ_CP116718:1798625-1798807 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22391.52 Da
• Isoelectric Point: 5.1445

>AT219800 WP_001251217.1 NZ_CP084892:c1996518-1995919 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIEFIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT219800 NZ_CP116718:1798835-1799239 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6