Detailed information of TA system TA219795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4898110..4898654
• Replicon: chromosome
• Accession: NZ_CP084891
• Organism: Xanthomonas citri pv. mangiferaeindicae strain GZ09

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LCZ91_RS21205
• Protein ID: WP_015462700.1
• Coordinates: 4898376..4898654 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: LCZ91_RS21200
• Protein ID: WP_003487884.1
• Coordinates: 4898110..4898367 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCZ91_RS21180 (LCZ91_21180)	4893165..4894127	-	963	WP_011347617.1	IS1595-like element IS1595 family transposase	-
LCZ91_RS21185 (LCZ91_21185)	4894198..4894710	-	513	Protein_4152	exonuclease	-
LCZ91_RS21190 (LCZ91_21190)	4894707..4897202	-	2496	WP_003487880.1	DEAD/DEAH box helicase	-
LCZ91_RS21195 (LCZ91_21195)	4897380..4898042	+	663	WP_005912558.1	hemolysin III family protein	-
LCZ91_RS21200 (LCZ91_21200)	4898110..4898367	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LCZ91_RS21205 (LCZ91_21205)	4898376..4898654	+	279	WP_015462700.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LCZ91_RS21215 (LCZ91_21215)	4898834..4899733	-	900	WP_003487887.1	SDR family NAD(P)-dependent oxidoreductase	-
LCZ91_RS21220 (LCZ91_21220)	4899792..4900529	-	738	WP_003487890.1	SDR family oxidoreductase	-
LCZ91_RS21225 (LCZ91_21225)	4900655..4901566	+	912	WP_003487892.1	LysR family transcriptional regulator	-
LCZ91_RS21230 (LCZ91_21230)	4901764..4902474	+	711	WP_003487894.1	hypothetical protein	-
LCZ91_RS21235 (LCZ91_21235)	4902715..4903323	-	609	WP_003487896.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4893165..4894127	962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10400.97 Da
• Isoelectric Point: 10.1557

>T219795 WP_015462700.1 NZ_CP084891:4898376-4898654 [Xanthomonas citri pv. mangiferaeindicae]
VPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHVMR
SERALRGNRLSR

Nucleotide

• Length: 279 bp

>T219795 NZ_CP116717:2872781-2873062 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT219795 WP_003487884.1 NZ_CP084891:4898110-4898367 [Xanthomonas citri pv. mangiferaeindicae]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT219795 NZ_CP116717:2872546-2872791 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Structures

Antitoxin

• AlphaFold DB: H8FI25