Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3627786..3628440 Replicon chromosome
Accession NZ_CP084879
Organism Shigella flexneri strain CMCC51574

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag LGV73_RS18490 Protein ID WP_000244767.1
Coordinates 3627786..3628193 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag LGV73_RS18495 Protein ID WP_000354044.1
Coordinates 3628174..3628440 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGV73_RS18470 (3623743) 3623743..3625476 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
LGV73_RS18475 (3625482) 3625482..3626192 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGV73_RS18480 (3626217) 3626217..3627113 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
LGV73_RS18485 (3627225) 3627225..3627746 + 522 WP_001055867.1 flavodoxin FldB -
LGV73_RS18490 (3627786) 3627786..3628193 - 408 WP_000244767.1 protein YgfX Toxin
LGV73_RS18495 (3628174) 3628174..3628440 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
LGV73_RS18500 (3628683) 3628683..3629663 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
LGV73_RS18505 (3629859) 3629859..3630518 - 660 WP_000250274.1 hemolysin III family protein -
LGV73_RS18510 (3630682) 3630682..3630992 - 311 Protein_3607 N(4)-acetylcytidine aminohydrolase -
LGV73_RS18515 (3631037) 3631037..3632470 + 1434 WP_005076748.1 6-phospho-beta-glucosidase BglA -
LGV73_RS18520 (3632527) 3632527..3633270 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T219792 WP_000244767.1 NZ_CP084879:c3628193-3627786 [Shigella flexneri]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T219792 NZ_CP116717:c167171-166890 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT219792 WP_000354044.1 NZ_CP084879:c3628440-3628174 [Shigella flexneri]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219792 NZ_CP116717:c167395-167168 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References