Detailed information of TA system TA021979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/-
• Location: 2055690..2057062
• Replicon: chromosome
• Accession: NC_009085
• Organism: Acinetobacter baumannii ATCC 17978

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: A1S_1765
• Protein ID: YP_001084794.1
• Coordinates: 2055995..2057062 (-)
• Length: 356 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: A1S_1764
• Protein ID: YP_001084793.1
• Coordinates: 2055690..2055935 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1S_1761	2051254..2051709	-	456	YP_001084790.1	acetyltransferase	-
A1S_1762	2052477..2053559	-	1083	YP_001084791.1	hypothetical protein	-
A1S_1763	2054413..2054784	-	372	YP_001084792.1	transcriptional regulator	-
A1S_1764	2055690..2055935	-	246	YP_001084793.1	transcriptional regulator	Antitoxin
A1S_1765	2055995..2057062	-	1068	YP_001084794.1	hypothetical protein	Toxin
A1S_1766	2058097..2058582	-	486	YP_001084795.1	hypothetical protein	-
A1S_1767	2058753..2059523	-	771	YP_001084796.1	acid phosphatase	-
A1S_1768	2059851..2060915	-	1065	YP_001084797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (79-271)

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-61)

Sequences

Toxin

Protein

• Length: 356 a.a.
• Molecular weight: 41041.52 Da
• Isoelectric Point: 4.7374

>T21979 YP_001084794.1 NC_009085:c2057062-2055995 [Acinetobacter baumannii ATCC 17978]
VNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAISGGATGAG
GEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQMQLIEGTKY
PSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLLNIIFGNSD
NHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLRTLANNLLG
LKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1068 bp

>T21979 NC_009085:c2057062-2055995 [Acinetobacter baumannii ATCC 17978]
GTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATTAGAAAAAGGTGGGATGGCACCTGT
TGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGCACTTACGTTATTTTAGTAAGGAAG
ATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATTAGTGGTGGTGCAACTGGTGCAGGC
GGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGACACCTACCAAGAACAATTTGATCA
GCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAATCGTAGCGAGATTGATTGCGATATTCTCAGAGCTGAATATT
ATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATGCAGCTTATTGAAGGTACAAAATAT
CCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCGCTATGGTCTAGAGTCTGTGTATTC
TGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATCTATGTAGATTACTCACAAGCATTG
ACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGCGACTTACTCAATATCATTTTTGGCAATTCAGAT
AACCACGGTCGGAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCCTATTTATGACTTTGCACCTATGAA
AGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTATGAGGAAGGAGGTGAATACCGGTGGGCACAAA
TTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGGACTTTGGCGAATAACCTGCTTGGC
TTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGCGCTGTCATTTGATTACATAGAAGC
TAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9026.58 Da
• Isoelectric Point: 10.0042

>AT21979 YP_001084793.1 NC_009085:c2055935-2055690 [Acinetobacter baumannii ATCC 17978]
MLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPLGLKAGLVPTHEHIVSKIIKPN
E

Nucleotide

• Length: 246 bp

>AT21979 NC_009085:c2055935-2055690 [Acinetobacter baumannii ATCC 17978]
TTGTTGAGTGAGATTACTTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGC
TAATTTGGTGGGTATAAGCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATA
AAGTGTTTAAACCACTTGGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAAC
GAGTAA