Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2697385..2698040 Replicon chromosome
Accession NC_009080
Organism Burkholderia mallei NCTC 10247

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BMA10247_RS22125 Protein ID WP_004199884.1
Coordinates 2697385..2697681 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BMA10247_RS22130 Protein ID WP_004202809.1
Coordinates 2697684..2698040 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMA10247_RS22100 2692943..2693509 - 567 WP_004525805.1 hypothetical protein -
BMA10247_RS22105 2693845..2694309 - 465 WP_073699083.1 hypothetical protein -
BMA10247_RS22110 2694865..2695305 + 441 WP_009935860.1 BPSL0067 family protein -
BMA10247_RS32770 2695292..2695429 + 138 WP_004202832.1 hypothetical protein -
BMA10247_RS22125 2697385..2697681 + 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMA10247_RS22130 2697684..2698040 + 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BMA10247_RS22135 2698084..2699139 - 1056 WP_004199886.1 phage portal protein -
BMA10247_RS22140 2699136..2699633 - 498 WP_004199888.1 terminase -
BMA10247_RS22150 2699855..2700376 - 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BMA10247_RS22155 2700446..2701057 - 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BMA10247_RS22160 2701150..2701908 - 759 WP_004199892.1 cytochrome c1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2695457..2699450 3993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T21978 WP_004199884.1 NC_009080:2697385-2697681 [Burkholderia mallei NCTC 10247]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T21978 NC_009080:2697385-2697681 [Burkholderia mallei NCTC 10247]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT21978 WP_004202809.1 NC_009080:2697684-2698040 [Burkholderia mallei NCTC 10247]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT21978 NC_009080:2697684-2698040 [Burkholderia mallei NCTC 10247]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References