Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2433499..2434022 Replicon chromosome
Accession NZ_CP084878
Organism Staphylococcus aureus strain GS426

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag LD199_RS11960 Protein ID WP_000074049.1
Coordinates 2433499..2433765 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LD199_RS11965 Protein ID WP_000587616.1
Coordinates 2433765..2434022 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD199_RS11940 (LD199_11940) 2428806..2429993 - 1188 WP_000026189.1 MFS transporter -
LD199_RS11945 (LD199_11945) 2430389..2431165 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
LD199_RS11950 (LD199_11950) 2431158..2431820 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
LD199_RS11955 (LD199_11955) 2432068..2433144 - 1077 WP_001076673.1 M42 family metallopeptidase -
LD199_RS11960 (LD199_11960) 2433499..2433765 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
LD199_RS11965 (LD199_11965) 2433765..2434022 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LD199_RS11970 (LD199_11970) 2434381..2434836 + 456 WP_000732076.1 DUF1307 domain-containing protein -
LD199_RS11975 (LD199_11975) 2435004..2436581 - 1578 WP_217660831.1 FMN-binding glutamate synthase family protein -
LD199_RS11980 (LD199_11980) 2436776..2437525 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T219773 WP_000074049.1 NZ_CP084878:c2433765-2433499 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T219773 NZ_CP116700:c318547-318296 [Agrobacterium fabacearum]
GTGATCTGGACAATTGAATACGATGTTCTTGTCCAGAAAGAGATGCGGAAAATCGATCCGCAGACGCGTCAGCGTATCCG
AGTAGCGGCGCTCGACAATCCCCGCCAGACAGGTGCCGCCCTGCAAGGCTCAGAACTCGGCAGCTTCTGGCGTTACCGGG
TAGGCGATTACCGTATCATCTGCGATATACAGGACCACAAGCTTGTCGTGCTGGTGGTGGAAATTGGCCATCGCCGCGAA
ATTTACCGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT219773 WP_000587616.1 NZ_CP084878:c2434022-2433765 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT219773 NZ_CP116700:c318758-318531 [Agrobacterium fabacearum]
ATGAGCAAACAGACTGCCATCCGCCTGCCGGACGAGACCTATGAACGGCTGAAAGCGCTTTCCGAGCGCACGGGCCGTAC
GTCCGCATACTATATCCGCGAGGCGATTGAGAAACATATTGAGGATATGGAAGATCTCTATCTAGCCGAAGAGGCGACGC
GGCGCATCCAGCGCGGTGAATCAAAGGTGGTAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References