Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1792165..1792642 Replicon chromosome
Accession NZ_CP084878
Organism Staphylococcus aureus strain GS426

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LD199_RS08710 Protein ID WP_000052076.1
Coordinates 1792454..1792642 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LD199_RS08705 Protein ID WP_001059690.1
Coordinates 1792165..1792425 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD199_RS08670 (LD199_08670) 1787558..1788274 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
LD199_RS08675 (LD199_08675) 1788422..1788844 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
LD199_RS08680 (LD199_08680) 1789243..1789737 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
LD199_RS08685 (LD199_08685) 1789892..1790509 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
LD199_RS08690 (LD199_08690) 1790582..1791163 - 582 WP_001140693.1 histidine phosphatase family protein -
LD199_RS08695 (LD199_08695) 1791388..1791624 + 237 WP_000349581.1 hypothetical protein -
LD199_RS08700 (LD199_08700) 1791621..1791824 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LD199_RS08705 (LD199_08705) 1792165..1792425 + 261 WP_001059690.1 hypothetical protein Antitoxin
LD199_RS08710 (LD199_08710) 1792454..1792642 + 189 WP_000052076.1 hypothetical protein Toxin
LD199_RS08715 (LD199_08715) 1792830..1793399 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
LD199_RS08720 (LD199_08720) 1793487..1793771 + 285 WP_001004399.1 hypothetical protein -
LD199_RS08725 (LD199_08725) 1793833..1794051 + 219 WP_000005886.1 hypothetical protein -
LD199_RS08730 (LD199_08730) 1794543..1794743 - 201 WP_001059082.1 cold-shock protein -
LD199_RS08735 (LD199_08735) 1795100..1795786 - 687 WP_000141557.1 thermonuclease family protein -
LD199_RS08740 (LD199_08740) 1796127..1796648 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T219769 WP_000052076.1 NZ_CP084878:1792454-1792642 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T219769 NZ_CP116697:c11179-9938 [Agrobacterium fabacearum]
ATGACAACCATCTACTACGAGACCTTACCTGTCGCCCATCTGAGTTTTGAAGGCGAATGGAGGTTGGACTATGATCCGGG
CTGGGAAGCACGCCGCCCGGCCTTTCCGGTGTCGCTTACCATGCCGCTGCGTTCCGGATCCGTGGGTGCAGCAAAGCTGC
TTCCCTGGCTTGCCAATCTGCTTCCGGAAACCCATCTTGCCGAGATCGGTCAGCGCCTCAAGGTTTCCCCGCAAGATATT
GTCGGTCTACTTGCTCATATCGGGCGTGACACGGCGGGGGCACTGTCGATCGGGGAGCCGCGGAAAGCTGGCGTCAACCT
CCAGCCCGTGCCGGACGAGCAGGCGCTGGAGCGTATTCTCAATGAACTTCCTGCCAAACCCTTTCTGGTCGGAGAGCGCG
GTGTTTCTATGTCCCTGGCGGGCGTTCAGGAGAAGCTGCCGGTGTTTGTTGAGGGGAGTGGCCGTATTTCAGTTCCGGTC
GACGGGACGCCATCCACGCATATTCTCAAGCCGGATACGAAACGCCTTGCGGGGAGCGTGGAGAACGAAGCCTTTTGCCT
GTCGCTTGCGCGTGCCTGCGGGCTGGATGCCGCCGAGGCGACGATCGGAGTAGCTGGCAAGCGACGTTATCTTCTCGTGA
AACGCTATGATCGCTTTACCGACGCTCAAGGCGAGATCCGCAGGCTGCATCAGGAGGATCTTTGCCAGTTAACGGGTTAC
TTCCCCTCGCAGAAATACGAGCGATCCTCGACCGGCCGCGGCGTGACCATGAAGATGATGTTTGACGCCGTCAGCGATCT
TGTTTCGCCTGGCGAGCGGTTGAAACTTCTCGATGCGGTGATCTTCAATGTCCTGATCTGCAATTCGGATTCGCATGCCA
AAAATTACTCTATCCTGATTGGTGCCGGTGGGTCCGCGAAGATGGCTCCACTCTATGATCTGATGTGCGCTGCCGTTTAT
CACCAGGTCGACCAGAGCCTGCCGCAGGAGATTTCCGGTCGGTTCCATGCGCCTGACCTGCGGCGTGCCGACTGGCAGGC
GCTGGCTGATGACATTGGACTGAGCGGCGCATCGACGCTGAAACGGGTGGAGGAGCTTGCAAAACTGGTCAACGTCGCAT
GCGATGAGGTGGCACGATATATCGTCGCCCTCTCCAGCGATCCGACGAGGATTCTTGAGCGAATTACTCACAGCATTCAA
AAGCGGTGCCGGCGAATTCAGGAGCAGATGCGTGATCGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT219769 WP_001059690.1 NZ_CP084878:1792165-1792425 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT219769 NZ_CP116697:c11448-11176 [Agrobacterium fabacearum]
ATGTTCAGGTCCGCGCGTGATTTCGGCGCTGCTATCAAGGAGAGACGCAAAGCACTTGGCTGGACGCAAACCGGGCTTGC
TGCCCGTTCCGGAACGGGGGAACGCTTCATCGTCGAGCTTGAATCGGGCAAGCCGAGTTGCCAGCTCGAAAAAGCCCTGA
TCGTCGCGCGCGCAGTTGGAATCGATCTTGGCGATCTCAAGACGGTTCAGACTGTGCAAGCCGCGCCGGACGATGACCTC
GGCTTTCTGCCGATGTTTGGTGCTGATCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References