Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 757275..758051 Replicon chromosome
Accession NZ_CP084878
Organism Staphylococcus aureus strain GS426

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LD199_RS03745 Protein ID WP_000031108.1
Coordinates 757899..758051 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LD199_RS03740 Protein ID WP_001251224.1
Coordinates 757275..757874 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD199_RS03720 (LD199_03720) 753191..754648 + 1458 WP_000649908.1 ABC transporter permease subunit -
LD199_RS03725 (LD199_03725) 754641..755363 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LD199_RS03730 (LD199_03730) 755514..756641 + 1128 WP_226566105.1 tRNA epoxyqueuosine(34) reductase QueG -
LD199_RS03735 (LD199_03735) 756646..757116 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LD199_RS03740 (LD199_03740) 757275..757874 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LD199_RS03745 (LD199_03745) 757899..758051 + 153 WP_000031108.1 SAS053 family protein Toxin
LD199_RS03750 (LD199_03750) 758599..758994 + 396 WP_000901023.1 hypothetical protein -
LD199_RS03755 (LD199_03755) 759190..760575 + 1386 WP_000116228.1 class II fumarate hydratase -
LD199_RS03760 (LD199_03760) 761028..761849 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T219766 WP_000031108.1 NZ_CP084878:757899-758051 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T219766 NZ_CP116692:c540067-539801 [Agrobacterium tumefaciens]
TTGAAAGACCGCACAGGAAAAGTGCGGATTCTACATCGTCTCACGGCGGCAGAGCATGGGAACTTCGGTGATTGTGAGCC
TGTGGGTGGCGGCGTTTCGGAAATGCGTATCCACCACGGTCCGGGTTATCGGGTCTATTTCACCCGCATTGGCAAGACAA
TCTATTTCCTTCTTGTCGGCGGCGACAAGTCTTCGCAGAAACGGGACATCAAGCGCGCAATCGAGATGGCGCAAACCATA
GGAAGGGATGGCCGTGACGGAATTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT219766 WP_001251224.1 NZ_CP084878:757275-757874 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT219766 NZ_CP116692:c539820-539521 [Agrobacterium tumefaciens]
ATGGCCGTGACGGAATTTAGCAAATTCGATGTGTCAGACTATCTGGATAGCGATGAAACCATGATCGAATATCTGGCTGT
CGCGATGGAAGATGAAAACCCCGATGTCTTCATCGCGGCCCTTGGCGCAGTCGCCCGCGCGCGTGGAATGTCGCACGTCG
CGGATGTTTCGGGCTTGGGGCGCGAAAGCCTCTATAAAGCGCTCAGGCCGGGTTCAAAGCTGCGCTACGAAACCGTTCAG
AGGGTGTTGCAGGCGCTCGGCTTCCGGCTGGCCGTCGAAAAATCGCTGAACGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References