Detailed information of TA system TA219766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 757275..758051
• Replicon: chromosome
• Accession: NZ_CP084878
• Organism: Staphylococcus aureus strain GS426

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: LD199_RS03745
• Protein ID: WP_000031108.1
• Coordinates: 757899..758051 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: LD199_RS03740
• Protein ID: WP_001251224.1
• Coordinates: 757275..757874 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LD199_RS03720 (LD199_03720)	753191..754648	+	1458	WP_000649908.1	ABC transporter permease subunit	-
LD199_RS03725 (LD199_03725)	754641..755363	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
LD199_RS03730 (LD199_03730)	755514..756641	+	1128	WP_226566105.1	tRNA epoxyqueuosine(34) reductase QueG	-
LD199_RS03735 (LD199_03735)	756646..757116	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LD199_RS03740 (LD199_03740)	757275..757874	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
LD199_RS03745 (LD199_03745)	757899..758051	+	153	WP_000031108.1	SAS053 family protein	Toxin
LD199_RS03750 (LD199_03750)	758599..758994	+	396	WP_000901023.1	hypothetical protein	-
LD199_RS03755 (LD199_03755)	759190..760575	+	1386	WP_000116228.1	class II fumarate hydratase	-
LD199_RS03760 (LD199_03760)	761028..761849	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T219766 WP_000031108.1 NZ_CP084878:757899-758051 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T219766 NZ_CP116692:c540067-539801 [Agrobacterium tumefaciens]
TTGAAAGACCGCACAGGAAAAGTGCGGATTCTACATCGTCTCACGGCGGCAGAGCATGGGAACTTCGGTGATTGTGAGCC
TGTGGGTGGCGGCGTTTCGGAAATGCGTATCCACCACGGTCCGGGTTATCGGGTCTATTTCACCCGCATTGGCAAGACAA
TCTATTTCCTTCTTGTCGGCGGCGACAAGTCTTCGCAGAAACGGGACATCAAGCGCGCAATCGAGATGGCGCAAACCATA
GGAAGGGATGGCCGTGACGGAATTTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT219766 WP_001251224.1 NZ_CP084878:757275-757874 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT219766 NZ_CP116692:c539820-539521 [Agrobacterium tumefaciens]
ATGGCCGTGACGGAATTTAGCAAATTCGATGTGTCAGACTATCTGGATAGCGATGAAACCATGATCGAATATCTGGCTGT
CGCGATGGAAGATGAAAACCCCGATGTCTTCATCGCGGCCCTTGGCGCAGTCGCCCGCGCGCGTGGAATGTCGCACGTCG
CGGATGTTTCGGGCTTGGGGCGCGAAAGCCTCTATAAAGCGCTCAGGCCGGGTTCAAAGCTGCGCTACGAAACCGTTCAG
AGGGTGTTGCAGGCGCTCGGCTTCCGGCTGGCCGTCGAAAAATCGCTGAACGCCGCGTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4