Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 583678..584192 Replicon chromosome
Accession NZ_CP084878
Organism Staphylococcus aureus strain GS426

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LD199_RS02755 Protein ID WP_000581792.1
Coordinates 583983..584192 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LD199_RS02750 Protein ID WP_000138932.1
Coordinates 583678..583971 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LD199_RS02730 (LD199_02730) 578841..579482 + 642 WP_094637925.1 thiamine phosphate synthase -
LD199_RS02735 (LD199_02735) 579568..580440 + 873 WP_000725802.1 membrane protein insertase YidC -
LD199_RS02740 (LD199_02740) 581353..582000 - 648 WP_001187630.1 HD domain-containing protein -
LD199_RS02745 (LD199_02745) 582028..583512 - 1485 WP_000571549.1 cardiolipin synthase -
LD199_RS02750 (LD199_02750) 583678..583971 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LD199_RS02755 (LD199_02755) 583983..584192 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LD199_RS02760 (LD199_02760) 584320..584457 + 138 WP_000828354.1 Lmo0850 family protein -
LD199_RS02765 (LD199_02765) 584721..585923 - 1203 WP_226566098.1 FtsW/RodA/SpoVE family cell cycle protein -
LD199_RS02770 (LD199_02770) 586241..587311 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LD199_RS02775 (LD199_02775) 587326..588684 + 1359 WP_226566099.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T219764 WP_000581792.1 NZ_CP084878:583983-584192 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T219764 NZ_CP116690:149133-149426 [Agrobacterium tumefaciens]
ATGCTGTTCAGCCTTTCGGTTCAAGCGGAAGAGGATATTGTTTCCATTGCAGAAGAAGGCATTCGCATCTTCGGAGCACT
GGTTGCCAAACGATATCACGATGAGCTTTTAGCCTTGCTCGAAATCATCGCCACCAACCCAAGAATGGCGCGTGAACGAC
ATGAGATTTCTCCTCCTGTCAGGATCCATCCCTTCAAGGCCCACCTTGTAGTTTATCGCATCGTTGAAGATGGGAGCATA
TTCGTGATCCGCATCCGGCATGGACATGAAGATTGGGCAGGAGACTCTTTCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT219764 WP_000138932.1 NZ_CP084878:583678-583971 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT219764 NZ_CP116690:148879-149133 [Agrobacterium tumefaciens]
ATGGCGACGATGAATGTATCCCTACCTGACCCCATGAAAGATTGGGTCGAAGCACAGGCCAAGACGGGTCGATACTCGAA
CGCGAGCGATTATGTCAGGGACCTGATCCGCAGAGACCAAGCTCGTACGGACAAGATTGCCGAGATGCAGCGCTTTGTCG
ACGACGGGATTAGAAGCGGAGTTGGGAGCCGTTCAATGGACGAGTTGTTTGCTGAAGCCACCGCTCGATCCGAGATCAGC
CGCGGACGCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References