Detailed information of TA system TA219758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4789701..4790217
• Replicon: chromosome
• Accession: NZ_CP084876
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain 01A030T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGM20_RS22950
• Protein ID: WP_044525202.1
• Coordinates: 4789701..4789985 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: LGM20_RS22955
• Protein ID: WP_023291757.1
• Coordinates: 4789975..4790217 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM20_RS22940 (4786699)	4786699..4788837	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
LGM20_RS22945 (4789233)	4789233..4789697	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGM20_RS22950 (4789701)	4789701..4789985	-	285	WP_044525202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGM20_RS22955 (4789975)	4789975..4790217	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGM20_RS22960 (4790295)	4790295..4792205	-	1911	WP_044525201.1	PRD domain-containing protein	-
LGM20_RS22965 (4792228)	4792228..4793379	-	1152	WP_023291755.1	lactonase family protein	-
LGM20_RS22970 (4793446)	4793446..4794186	-	741	WP_017900574.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10965.82 Da
• Isoelectric Point: 10.4974

>T219758 WP_044525202.1 NZ_CP084876:c4789985-4789701 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MTYELAFDPRAWREWHKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T219758 NZ_CP116688:c331238-330969 [Agrobacterium tumefaciens]
GTGATCTGGACAATTGAATATCACACGCTTGTCCAGAAAGAGATGCGCAAGATAAATCCGGAAGTGCGCCGGCGTATCCG
CAGCTTTCTCCATGAAAGGCTGGCGGCGCTGGACGACCCGCGCCAAACCGGCGCGGCCCTTCAGGGTTCCGAACTCGGAA
ACTACTGGCGTTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGACCACAAGCTGGTCGTTCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATTTACCGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT219758 WP_023291757.1 NZ_CP084876:c4790217-4789975 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT219758 NZ_CP116688:c331449-331222 [Agrobacterium tumefaciens]
ATGAGCAAACAGACGGCCATCCGCTTGCCTGATGAGACCTATGAGCGGCTGAAGGCGCTGTCTGAGCGCACCGGCCGCAC
ATCCGCTTACTATATCCGCGAGGCGATCGAGAAACATATCGAGGATATGGAAGACCTCTATCTTGCCGAAGAGGCGACGC
GGCGCATCCAGCGCGGAGAATCGAAGGTTATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86