Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4063991..4064610 Replicon chromosome
Accession NZ_CP084876
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain 01A030T

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM20_RS19580 Protein ID WP_002892050.1
Coordinates 4064392..4064610 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM20_RS19575 Protein ID WP_002892066.1
Coordinates 4063991..4064365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM20_RS19565 (4059145) 4059145..4060338 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM20_RS19570 (4060361) 4060361..4063507 + 3147 WP_044521296.1 multidrug efflux RND transporter permease subunit AcrB -
LGM20_RS19575 (4063991) 4063991..4064365 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM20_RS19580 (4064392) 4064392..4064610 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM20_RS19585 (4064769) 4064769..4065335 + 567 WP_023288643.1 maltose O-acetyltransferase -
LGM20_RS19590 (4065307) 4065307..4065429 - 123 WP_044521294.1 hypothetical protein -
LGM20_RS19595 (4065472) 4065472..4065942 + 471 WP_023288642.1 YlaC family protein -
LGM20_RS19600 (4065911) 4065911..4067368 - 1458 WP_044521291.1 PLP-dependent aminotransferase family protein -
LGM20_RS19605 (4067469) 4067469..4068167 + 699 WP_044521289.1 GNAT family protein -
LGM20_RS19610 (4068164) 4068164..4068304 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM20_RS19615 (4068304) 4068304..4068567 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219757 WP_002892050.1 NZ_CP084876:4064392-4064610 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219757 NZ_CP116688:c94147-93959 [Agrobacterium tumefaciens]
ATGAAGAGTGGCGATATCATTTCGGCATTGAAAGCGGATGGCTGGTACGAGGTTGGCACCAGAGGCAGTCATGTCCAATT
CAAACACCCGACGAAACAAGGCCGTGTGACCGTTCCTCACCCGAGGAGAGATTTGCCGATAGGGACGCTCAAGAGCATCG
AGAAACAATCTGGACTGAAACTGAGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219757 WP_002892066.1 NZ_CP084876:4063991-4064365 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219757 NZ_CP116688:c93954-93526 [Agrobacterium tumefaciens]
ATGCGTAACTATATCGGACTGATCCACAAGGACGCTGATAGCGATTACGGCGTTTCCTTTCCTGATTTTCCCGGTGTTAT
AACTGCTGGCACCGATCTTGACGATGCTCGTCACATGGCGGAGGAAGCCCTGGCGCTGCATGTTGAAGGGATGATCGAAG
ATGGTGAAGCCATTCCCGAACCGTCTTCCCTCGAAACCGTCATGGCTGATGCGGAAAACAAGGACGGGGTGGCTATTCTG
GTTACCCTCAAGACAGAGAGCAAAAAATCTGTCCGTATTAACATCACACTTCCAGAAGATGTCTTGAAGGCAATTGACGC
GTTCGCGGAGGCGCGGGGGCTGACACGGTCTGGTTTCCTTGCGCGCGCAGCTAAACACGAAATGTCGAGTGTAAGTGAGG
ATGACGATTGGCGAGAGTTTGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References