Detailed information of TA system TA219756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2663782..2665370
• Replicon: chromosome
• Accession: NZ_CP084876
• Organism: Klebsiella quasipneumoniae subsp. quasipneumoniae strain 01A030T

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGM20_RS12955
• Protein ID: WP_044523012.1
• Coordinates: 2663782..2665104 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LGM20_RS12960
• Protein ID: WP_044523009.1
• Coordinates: 2665104..2665370 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM20_RS12940 (2658814)	2658814..2661339	+	2526	WP_044523020.1	fimbria/pilus outer membrane usher protein	-
LGM20_RS12945 (2661327)	2661327..2662331	+	1005	WP_044523017.1	fimbrial protein	-
LGM20_RS12950 (2662473)	2662473..2663765	+	1293	WP_044523014.1	glycoside hydrolase family 10 protein	-
LGM20_RS12955 (2663782)	2663782..2665104	-	1323	WP_044523012.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGM20_RS12960 (2665104)	2665104..2665370	-	267	WP_044523009.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGM20_RS12965 (2665635)	2665635..2665961	-	327	WP_044523006.1	hydroxyisourate hydrolase	-
LGM20_RS12970 (2665958)	2665958..2666458	-	501	WP_044523003.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGM20_RS12975 (2666436)	2666436..2667815	-	1380	WP_044523001.1	nucleobase:cation symporter-2 family protein	-
LGM20_RS12980 (2668161)	2668161..2669315	+	1155	WP_023289663.1	FAD-dependent urate hydroxylase HpxO	-
LGM20_RS12985 (2669296)	2669296..2670219	-	924	WP_044522995.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49183.49 Da
• Isoelectric Point: 8.6110

>T219756 WP_044523012.1 NZ_CP084876:c2665104-2663782 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T219756 NZ_CP116683:c2055715-2055431 [Agrobacterium fabrum]
ATGCAGCAAAAGGGTACGATTGCTCTCGGCTGGAGCCACGAAGGTTGGGAAGATTATCTTCACTGGCAGAAATATGATCG
CAAGATGCTTGAACGCATCAACGAACTCATAAAGGACTGTCGGCGACATCCCTTCGAGGGCATCGGGAAACCAGAGCCTC
TGCGTTTCCAGTTGAAGGGCCTGTGGTCCCGCCGGATTTCGCAGGAGCATCGGCTTGTCTATGAGCTTCGCGGCGACGGT
GAAAAGGCGGTGCTGATTATCCACCAATGCCGCTTCCACTACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9901.29 Da
• Isoelectric Point: 7.3163

>AT219756 WP_044523009.1 NZ_CP084876:c2665370-2665104 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MHPPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT219756 NZ_CP116683:c2056018-2055767 [Agrobacterium fabrum]
ATGCGTACTGTTATTTTCTCGAAAGCACGCGAATCCCTTGCATCGCTTCTGGATGAAGTGTCGCAGGATCGGGTGGCTGT
GGAAATTGTACGGCGTGACAAGCCGTCCGCCGTTCTTATCGATAAGGACGAATACGAAGGCTTGCTGGAAACCTTGCATC
TATGCTCGTCACCAGAGAATTTTGCCAGACTTAGAAAGTCGATGTCTGACGTGGATACTGGTGTTTTCGAAAGCCATGAT
CTCATCGACTGA