Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835151..835808 Replicon chromosome
Accession NZ_CP084876
Organism Klebsiella quasipneumoniae subsp. quasipneumoniae strain 01A030T

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag LGM20_RS04175 Protein ID WP_023290968.1
Coordinates 835398..835808 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM20_RS04170 Protein ID WP_002916312.1
Coordinates 835151..835417 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM20_RS04145 (830310) 830310..831743 - 1434 WP_044524684.1 6-phospho-beta-glucosidase -
LGM20_RS04150 (831862) 831862..832590 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
LGM20_RS04155 (832641) 832641..832952 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
LGM20_RS04160 (833116) 833116..833775 + 660 WP_008806429.1 hemolysin III family protein -
LGM20_RS04165 (833922) 833922..834905 - 984 WP_044524683.1 tRNA-modifying protein YgfZ -
LGM20_RS04170 (835151) 835151..835417 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM20_RS04175 (835398) 835398..835808 + 411 WP_023290968.1 protein YgfX Toxin
LGM20_RS04180 (835815) 835815..836336 - 522 WP_004205324.1 flavodoxin FldB -
LGM20_RS04185 (836437) 836437..837333 + 897 WP_044524682.1 site-specific tyrosine recombinase XerD -
LGM20_RS04190 (837356) 837356..838069 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM20_RS04195 (838075) 838075..839808 + 1734 WP_044524681.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T219747 WP_023290968.1 NZ_CP084876:835398-835808 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219747 NZ_CP116682:2539805-2540086 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGCCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGCGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219747 WP_002916312.1 NZ_CP084876:835151-835417 [Klebsiella quasipneumoniae subsp. quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219747 NZ_CP116682:2539570-2539815 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References