Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5154462..5155087 Replicon chromosome
Accession NZ_CP084874
Organism Klebsiella africana strain 200023

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LGL98_RS24740 Protein ID WP_136031286.1
Coordinates 5154462..5154845 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LGL98_RS24745 Protein ID WP_168435282.1
Coordinates 5154845..5155087 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL98_RS24725 (LGL98_24725) 5151829..5152731 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LGL98_RS24730 (LGL98_24730) 5152728..5153363 + 636 WP_008807902.1 formate dehydrogenase cytochrome b556 subunit -
LGL98_RS24735 (LGL98_24735) 5153360..5154289 + 930 WP_136031288.1 formate dehydrogenase accessory protein FdhE -
LGL98_RS24740 (LGL98_24740) 5154462..5154845 - 384 WP_136031286.1 type II toxin-antitoxin system VapC family toxin Toxin
LGL98_RS24745 (LGL98_24745) 5154845..5155087 - 243 WP_168435282.1 CopG family transcriptional regulator Antitoxin
LGL98_RS24750 (LGL98_24750) 5155292..5156209 + 918 WP_136031282.1 alpha/beta hydrolase -
LGL98_RS24755 (LGL98_24755) 5156223..5157164 - 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
LGL98_RS24760 (LGL98_24760) 5157209..5157646 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LGL98_RS24765 (LGL98_24765) 5157643..5158503 - 861 WP_136031280.1 virulence factor BrkB family protein -
LGL98_RS24770 (LGL98_24770) 5158497..5159096 - 600 WP_136031279.1 glucose-1-phosphatase -
LGL98_RS24775 (LGL98_24775) 5159227..5160012 - 786 WP_136031277.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14361.64 Da        Isoelectric Point: 8.0552

>T219745 WP_136031286.1 NZ_CP084874:c5154845-5154462 [Klebsiella africana]
MTCGSALFDTNILIDLFSGRREAKQALEARPPQNAISLITWMEVMVGAKKYHQEQRTRMALSAFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTRDFAGIPGVVTPYELHPE

Download         Length: 384 bp

>T219745 NZ_CP116682:1685790-1686659 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACACCCCCGTCCCGAACCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGCTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGTTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGCCGCC
TGGTGCTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCTTCGGTATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGTCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9551.82 Da        Isoelectric Point: 4.2500

>AT219745 WP_168435282.1 NZ_CP084874:c5155087-5154845 [Klebsiella africana]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDQAKDIISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT219745 NZ_CP116682:1686652-1687485 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTTTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References