Detailed information of TA system TA219744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4835425..4837106
• Replicon: chromosome
• Accession: NZ_CP084874
• Organism: Klebsiella africana strain 200023

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGL98_RS23255
• Protein ID: WP_136029805.1
• Coordinates: 4835425..4836342 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LGL98_RS23260
• Protein ID: WP_136029802.1
• Coordinates: 4836348..4837106 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL98_RS23235 (LGL98_23235)	4830731..4832251	+	1521	WP_136029809.1	sugar ABC transporter ATP-binding protein	-
LGL98_RS23240 (LGL98_23240)	4832248..4833246	+	999	WP_002885172.1	ribose ABC transporter permease	-
LGL98_RS23245 (LGL98_23245)	4833277..4834218	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LGL98_RS23250 (LGL98_23250)	4834293..4835300	+	1008	WP_136029807.1	carbohydrate kinase family protein	-
LGL98_RS23255 (LGL98_23255)	4835425..4836342	-	918	WP_136029805.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGL98_RS23260 (LGL98_23260)	4836348..4837106	-	759	WP_136029802.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGL98_RS23265 (LGL98_23265)	4837192..4837920	-	729	WP_136029801.1	response regulator transcription factor	-
LGL98_RS23270 (LGL98_23270)	4838193..4840340	+	2148	WP_136029799.1	formate dehydrogenase subunit alpha	-
LGL98_RS23275 (LGL98_23275)	4840570..4841256	+	687	WP_136029797.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34536.99 Da
• Isoelectric Point: 5.7839

>T219744 WP_136029805.1 NZ_CP084874:c4836342-4835425 [Klebsiella africana]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIADNLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLAVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDARELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIGLEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLAKLEKVLAECRS

Nucleotide

• Length: 918 bp

>T219744 NZ_CP116682:c160386-160105 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28565.01 Da
• Isoelectric Point: 10.1009

>AT219744 WP_136029802.1 NZ_CP084874:c4837106-4836348 [Klebsiella africana]
MPTKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWLGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDVKGKILIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWFKRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219744 NZ_CP116682:c160610-160383 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA