Detailed information of TA system TA219743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4669345..4669861
• Replicon: chromosome
• Accession: NZ_CP084874
• Organism: Klebsiella africana strain 200023

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGL98_RS22435
• Protein ID: WP_136030901.1
• Coordinates: 4669345..4669629 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LGL98_RS22440
• Protein ID: WP_136030903.1
• Coordinates: 4669619..4669861 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL98_RS22425 (LGL98_22425)	4666298..4668436	+	2139	WP_136030897.1	anaerobic ribonucleoside-triphosphate reductase	-
LGL98_RS22430 (LGL98_22430)	4668877..4669341	+	465	WP_136030899.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LGL98_RS22435 (LGL98_22435)	4669345..4669629	-	285	WP_136030901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL98_RS22440 (LGL98_22440)	4669619..4669861	-	243	WP_136030903.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LGL98_RS22445 (LGL98_22445)	4669939..4671849	-	1911	WP_136030904.1	PRD domain-containing protein	-
LGL98_RS22450 (LGL98_22450)	4671872..4673026	-	1155	WP_136030906.1	lactonase family protein	-
LGL98_RS22455 (LGL98_22455)	4673326..4674066	-	741	WP_136030908.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11152.03 Da
• Isoelectric Point: 10.3787

>T219743 WP_136030901.1 NZ_CP084874:c4669629-4669345 [Klebsiella africana]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKAPGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T219743 NZ_CP116681:2762-3049 [Acinetobacter baumannii Canada BC-5]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9059.57 Da
• Isoelectric Point: 6.3340

>AT219743 WP_136030903.1 NZ_CP084874:c4669861-4669619 [Klebsiella africana]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVTLDDL

Nucleotide

• Length: 243 bp

>AT219743 NZ_CP116681:3036-3350 [Acinetobacter baumannii Canada BC-5]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA