Detailed information of TA system TA219741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2630390..2631978
• Replicon: chromosome
• Accession: NZ_CP084874
• Organism: Klebsiella africana strain 200023

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGL98_RS12845
• Protein ID: WP_136034204.1
• Coordinates: 2630390..2631712 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LGL98_RS12850
• Protein ID: WP_136034491.1
• Coordinates: 2631712..2631978 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL98_RS12830 (LGL98_12830)	2625446..2627947	+	2502	WP_136034212.1	fimbria/pilus outer membrane usher protein	-
LGL98_RS12835 (LGL98_12835)	2627935..2628939	+	1005	WP_136034210.1	fimbrial protein	-
LGL98_RS12840 (LGL98_12840)	2629081..2630373	+	1293	WP_136034206.1	glycoside hydrolase family 10 protein	-
LGL98_RS12845 (LGL98_12845)	2630390..2631712	-	1323	WP_136034204.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGL98_RS12850 (LGL98_12850)	2631712..2631978	-	267	WP_136034491.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LGL98_RS12855 (LGL98_12855)	2632244..2632570	-	327	WP_136034202.1	hydroxyisourate hydrolase	-
LGL98_RS12860 (LGL98_12860)	2632567..2633067	-	501	WP_136034200.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LGL98_RS12865 (LGL98_12865)	2633045..2634424	-	1380	WP_136034198.1	nucleobase:cation symporter-2 family protein	-
LGL98_RS12870 (LGL98_12870)	2634770..2635924	+	1155	WP_136034196.1	FAD-dependent urate hydroxylase HpxO	-
LGL98_RS12875 (LGL98_12875)	2635905..2636828	-	924	WP_136034194.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49302.57 Da
• Isoelectric Point: 7.5367

>T219741 WP_136034204.1 NZ_CP084874:c2631712-2630390 [Klebsiella africana]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEALRWQTLDEAQLTSLLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLTLARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAMMSFLLGSSEALKDRNDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFMATAKAVNFPREQMLAILQEFAERVP
QTIESARRTLPADFSTHVWQAITENVLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T219741 NZ_CP116678:111635-111967 [Edwardsiella tarda]
ATGGTTTCACGTTTTGTACCGGATTCGGGTGATCTGATCTGGATTGATTTTGATCCCGTTGCAGGGCACGAACAAGGAGG
AAAGCGCCCCGCCGTCGTACTAAGTCCGTTTGCATACAACAATAAAGTCGGATTACTACTTTGCGTACCCTGTACAACTA
AGGTTAAGAATTATCCCTTTGAGGTAGAACTTTCGGGAGAACGTGACAGCGTAGCGTTAGCGGATCAGATCACTTGCGTT
GACTGGCGAGCTAGAAAAGTAACAAAAAAAGGTGCTATCAGCGCTATCGAGCTGGCCGATATAAGAGCTAAGGCAAAAGC
TCTTATCGGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9909.27 Da
• Isoelectric Point: 8.5912

>AT219741 WP_136034491.1 NZ_CP084874:c2631978-2631712 [Klebsiella africana]
MNSPQIYSPVQLASYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT219741 NZ_CP116678:111390-111635 [Edwardsiella tarda]
ATGGCACAAGTAGTAGTGAAAAAATGGGGCAATAGCCCGTCGGTACGCCTCCCGGTTGCAATAATGCAAGCCGCATCACT
TAACGTCGATGATACCGTTGATATTGCTGTAGAAGACGGTCGGATCGTGATCATCCCGGTGAAAGCAAAAGAGTATTCAC
TTGATGCGCTCTTAGCTGGGATCACCGAGGATAACATTCATGAAAGAATGGGCTTTGGCGAGCCGGTTGGAAAGGAGTTA
CTCTGA