Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 807766..808423 Replicon chromosome
Accession NZ_CP084874
Organism Klebsiella africana strain 200023

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGL98_RS03985 Protein ID WP_002916310.1
Coordinates 808013..808423 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGL98_RS03980 Protein ID WP_002916312.1
Coordinates 807766..808032 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL98_RS03955 (LGL98_03955) 802832..804265 - 1434 WP_136029134.1 6-phospho-beta-glucosidase BglA -
LGL98_RS03960 (LGL98_03960) 804384..805112 - 729 WP_136029428.1 MurR/RpiR family transcriptional regulator -
LGL98_RS03965 (LGL98_03965) 805163..805474 + 312 WP_136029136.1 N(4)-acetylcytidine aminohydrolase -
LGL98_RS03970 (LGL98_03970) 805638..806297 + 660 WP_061153356.1 hemolysin III family protein -
LGL98_RS03975 (LGL98_03975) 806537..807520 - 984 WP_136029139.1 tRNA-modifying protein YgfZ -
LGL98_RS03980 (LGL98_03980) 807766..808032 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGL98_RS03985 (LGL98_03985) 808013..808423 + 411 WP_002916310.1 protein YgfX Toxin
LGL98_RS03990 (LGL98_03990) 808430..808951 - 522 WP_004144730.1 flavodoxin FldB -
LGL98_RS03995 (LGL98_03995) 809052..809948 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGL98_RS04000 (LGL98_04000) 809971..810684 + 714 WP_136029141.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGL98_RS04005 (LGL98_04005) 810690..812423 + 1734 WP_136029143.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219729 WP_002916310.1 NZ_CP084874:808013-808423 [Klebsiella africana]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219729 NZ_CP116672:c4366035-4365532 [Xanthomonas hortorum pv. pelargonii]
ATGTGGCTGGGACTATCGGGCAGGTTCCGTGCGCGCTGGAGCGTGCAAATCCACCAGGAATGGAAGCGCAATTTATTGCT
CAACCGGCGCGACCTCACAGCAGAGCAGGTGGACCGTACCTCGGCGCTGATGGACCGAGCCATTCCGGATGCCCTGGTGA
CTGGCCACGAACCGTTGATAGCAGGGCTGCAGCTGCCCGATGCAGATGATCGCCACGTGCTGGCCGCTGCGATCCGCTGC
AGCGCCAGCGTGATCGTCACCTTCAACCTGAAAGATTTCCCGTCCGCCACGCTCGCTCCCTTTGGGATCGAGGCGCAGCA
CCCGGACGAGTTCATTGAGAATCTGTTCGATCTGGACCAGGCGGCCGTTGTCTCTGCCGCTCAACGCCAGCGTGCACAGC
TGACCAATCCAGGGATGGAAGTGGAGCGCTATCTGGAGGTGCTGCTACGGCAAGGACTCGTCCAGACCGTTAAAGCGTTG
ACCATTTACCGCACGGTTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219729 WP_002916312.1 NZ_CP084874:807766-808032 [Klebsiella africana]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219729 NZ_CP116672:c4366571-4366104 [Xanthomonas hortorum pv. pelargonii]
ATGTCGAACATTGCTCCGTCCAAGATGGTCCTGCCTGTCGAGCGCGAGGTCGCCGCTGCAGTGCAAGGCCAACGCGCCTT
GGCGGCCTACCTTGCCACCAGCTTCGAAACCCAGCGCATCCAGATCTTCGACGACCAGAACCAGGCCCATCAGGTGGAAT
TGCCCACCTCCGCACTGCGTCTGCTGATGGATATCCTGGCCGAGCTCGCCGATGGCAATGCGGTGCAGGTGGTGCCCATC
CACGCCGAGTTGACCACCCAGGAAGCTGCCGATCTGCTGAACGTTTCCCGGCCGCATATGGTCAAGTTGATGGAAGAGGG
CGCGCTGGCGTTCCACCGCACCGGCAGACATCGCCGCGTACGTTTTGCCGACCTGATGCAGTTCAAGCGCGAACGTGAGC
GCGCCAGTGAGCAGGCCATGCAGGAACTGGCCACGCAGGCCCAGGAGCTGGCGCTGGGATATCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References