Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3859561..3860180 Replicon chromosome
Accession NZ_CP084873
Organism Klebsiella pneumoniae strain 03-9138-2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGL99_RS18905 Protein ID WP_002892050.1
Coordinates 3859962..3860180 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGL99_RS18900 Protein ID WP_002892066.1
Coordinates 3859561..3859935 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL99_RS18890 (3854713) 3854713..3855906 + 1194 WP_226618821.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGL99_RS18895 (3855929) 3855929..3859075 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGL99_RS18900 (3859561) 3859561..3859935 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGL99_RS18905 (3859962) 3859962..3860180 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGL99_RS18910 (3860339) 3860339..3860905 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGL99_RS18915 (3860877) 3860877..3861017 - 141 WP_004147370.1 hypothetical protein -
LGL99_RS18920 (3861038) 3861038..3861508 + 471 WP_002892026.1 YlaC family protein -
LGL99_RS18925 (3861515) 3861515..3862972 - 1458 WP_029883993.1 PLP-dependent aminotransferase family protein -
LGL99_RS18930 (3863073) 3863073..3863771 + 699 WP_002892021.1 GNAT family protein -
LGL99_RS18935 (3863768) 3863768..3863908 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGL99_RS18940 (3863908) 3863908..3864171 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3864231..3865277 1046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219722 WP_002892050.1 NZ_CP084873:3859962-3860180 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219722 NZ_CP116621:3862151-3862537 [Proteus terrae]
ATGGTTATCTATAAAACAAAGATGTTCAAAAACAGTTTCAAGAAAATGCCTATCAATGATGCTGCTTTAATAGATATTGC
CAACGAAGTATATGCAGGACACTTTGAAGCTGACTTAGGTGGGGGGATTATCAAAAAACGGATCTGTATCCATGGAAAAG
GAAAGAGTAGTGGAATTAGAACAATTATATTTTATAAACAGGGAAGTAATTTATTCTTTGCTGATGGATGGAAAAAATCT
CACTTGAGCGCTAAAAAATCTAAAGAAATTACAGATGATGAACTAGAATCCTATAAAGATCTGGCAAAAGATCTCTTCAG
TGCAACTAAAAATAAAATAGATAAGATGGTTGCACTAGGCCTTTTAACGGAGGTTAAACATGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219722 WP_002892066.1 NZ_CP084873:3859561-3859935 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219722 NZ_CP116621:3862530-3862850 [Proteus terrae]
ATGACTGATAAAATGCAAGAAATGCTGAAATTTGCACAAGAAATGGAAGTTGCGGGAATAACTGATGGAGAATCGGCTAG
ACGAATTGCAGCGAGAATAAAAGCCAAAGAATTAAAAGAAAGATATGCTCACCTGACTCCAATGAATGGTGAAGATATAA
AAAGAATTCGCGAGCAAAATAATATTTCGCAATCGTCTCTTGCTTTAATACTAAATATGACAAAAGAGAGCGTATCAAAA
TGGGAGCGGAACGAAATTAAACCCAATGGAGCTGCATTGAGACTTTTGAATTTAATAGATAATAAAGCAATTTCAATCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References