Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2572796..2574384 | Replicon | chromosome |
| Accession | NZ_CP084873 | ||
| Organism | Klebsiella pneumoniae strain 03-9138-2 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | W8UI36 |
| Locus tag | LGL99_RS12605 | Protein ID | WP_002904792.1 |
| Coordinates | 2572796..2574118 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | LGL99_RS12610 | Protein ID | WP_004176198.1 |
| Coordinates | 2574118..2574384 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGL99_RS12590 (2567852) | 2567852..2570353 | + | 2502 | WP_029884184.1 | fimbria/pilus outer membrane usher protein | - |
| LGL99_RS12595 (2570341) | 2570341..2571345 | + | 1005 | WP_029884185.1 | fimbrial protein | - |
| LGL99_RS12600 (2571487) | 2571487..2572779 | + | 1293 | WP_016946381.1 | glycoside hydrolase family 10 protein | - |
| LGL99_RS12605 (2572796) | 2572796..2574118 | - | 1323 | WP_002904792.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LGL99_RS12610 (2574118) | 2574118..2574384 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| LGL99_RS12615 (2574771) | 2574771..2575097 | - | 327 | WP_004224757.1 | hydroxyisourate hydrolase | - |
| LGL99_RS12620 (2575094) | 2575094..2575594 | - | 501 | WP_004224756.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| LGL99_RS12625 (2575572) | 2575572..2576951 | - | 1380 | WP_014599164.1 | nucleobase:cation symporter-2 family protein | - |
| LGL99_RS12630 (2577297) | 2577297..2578451 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| LGL99_RS12635 (2578432) | 2578432..2579355 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.46 Da Isoelectric Point: 7.5357
>T219721 WP_002904792.1 NZ_CP084873:c2574118-2572796 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T219721 NZ_CP116621:3573322-3573795 [Proteus terrae]
ATGGATTTCCCTACAGATTTGAATGGATGGACAATCTACGCACATCCTTGCTTTAAACAACAATATGATGAATTACTACA
AAAAGTCGAAGCTCTGAAAAAAAAATATCCCGAAGATTATCAGAAAAAAGCAGATACAAAAATTTTTGCTCATGTATTGA
AATCTATAGTAAACATCACAAATGACCCACGGGCACCAGAGTTTAGGTTGGGTAATACTTTAGGAGAAGAAAATAAAAAT
TGGTCACGAATTAAATTAGTAAATGGAAGATATCGTTTATTTTTTAGATTCAGTTTTAAGGAAAAGATCATCATTCTGGC
ATGGATAAATGATAATGATACTTTGCGAACTTATGGCAATAAAACTGATGCTTACCGAGTCTTTGAGAAAAAACTAAAGA
AAGGTCATCCACCTAAAAATTGGAATGATTTATTTAGTGACTGTATAAATGAAGCTGACTGTCAGGATCCTTAA
ATGGATTTCCCTACAGATTTGAATGGATGGACAATCTACGCACATCCTTGCTTTAAACAACAATATGATGAATTACTACA
AAAAGTCGAAGCTCTGAAAAAAAAATATCCCGAAGATTATCAGAAAAAAGCAGATACAAAAATTTTTGCTCATGTATTGA
AATCTATAGTAAACATCACAAATGACCCACGGGCACCAGAGTTTAGGTTGGGTAATACTTTAGGAGAAGAAAATAAAAAT
TGGTCACGAATTAAATTAGTAAATGGAAGATATCGTTTATTTTTTAGATTCAGTTTTAAGGAAAAGATCATCATTCTGGC
ATGGATAAATGATAATGATACTTTGCGAACTTATGGCAATAAAACTGATGCTTACCGAGTCTTTGAGAAAAAACTAAAGA
AAGGTCATCCACCTAAAAATTGGAATGATTTATTTAGTGACTGTATAAATGAAGCTGACTGTCAGGATCCTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.36 Da Isoelectric Point: 8.5912
>AT219721 WP_004176198.1 NZ_CP084873:c2574384-2574118 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT219721 NZ_CP116621:3572980-3573315 [Proteus terrae]
ATGCTAACCCACGTTTGCACTGACAACATCGCTCTTGAAGCTGATTCAAAAATAACAGAACGTCATCAAACCACAATTCC
CGCGTCAATTAGAGAAGCTCTACATCTTAGTGGTGGAGATCGTATTCACTACAAATTACTAAGCACTGGTGATGTACTTA
TCTCACGTCACAGCGATGGATCTGAAGATCCTGTTATGGCATCGTTTCTTAATTTTCTCGCTCAAGATATAACTAATCAT
CCTCAAACCATTCAACCTCTCGATATATCTCGTGGTTTTGAATTAGTTGAAGGTATGGATATCAACCTTGACGATGACAT
CACCGATAACGAATAA
ATGCTAACCCACGTTTGCACTGACAACATCGCTCTTGAAGCTGATTCAAAAATAACAGAACGTCATCAAACCACAATTCC
CGCGTCAATTAGAGAAGCTCTACATCTTAGTGGTGGAGATCGTATTCACTACAAATTACTAAGCACTGGTGATGTACTTA
TCTCACGTCACAGCGATGGATCTGAAGATCCTGTTATGGCATCGTTTCTTAATTTTCTCGCTCAAGATATAACTAATCAT
CCTCAAACCATTCAACCTCTCGATATATCTCGTGGTTTTGAATTAGTTGAAGGTATGGATATCAACCTTGACGATGACAT
CACCGATAACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|