Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801070..801727 Replicon chromosome
Accession NZ_CP084873
Organism Klebsiella pneumoniae strain 03-9138-2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGL99_RS03950 Protein ID WP_002916310.1
Coordinates 801317..801727 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGL99_RS03945 Protein ID WP_002916312.1
Coordinates 801070..801336 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL99_RS03920 (796278) 796278..797711 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LGL99_RS03925 (797830) 797830..798558 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGL99_RS03930 (798608) 798608..798919 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGL99_RS03935 (799083) 799083..799742 + 660 WP_002916317.1 hemolysin III family protein -
LGL99_RS03940 (799841) 799841..800824 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LGL99_RS03945 (801070) 801070..801336 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGL99_RS03950 (801317) 801317..801727 + 411 WP_002916310.1 protein YgfX Toxin
LGL99_RS03955 (801734) 801734..802255 - 522 WP_002916308.1 flavodoxin FldB -
LGL99_RS03960 (802356) 802356..803252 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGL99_RS03965 (803275) 803275..803988 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGL99_RS03970 (803994) 803994..805727 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219712 WP_002916310.1 NZ_CP084873:801317-801727 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219712 NZ_CP116615:3699747-3700385 [Fontisphaera persica]
ATGAGTGCTCTAACTCCACAAAATGCGCTGATATTCCGCATTACTCACCTGGCTAATATTCCCTGGCTATTGGATCATGG
CCTGCATTGCCAAAGCGCCCCCCAACGAGACCCTCATTTCCATGCTCTCGGCAATCCGGAGTTGATTGCGCGCCGCCAGC
ACCGCCGCGTGCCCATTGCCCCCGGGGGCACTCTGGCCGATTACGTGCCGTTTTACTTCACGCCCTATTCCATCATGCTT
TACAATATCAAGACGGGTCATGGGGGAGTTCCCCACGTCGCCAACGAACAGATTGTTTTTCTGGTGAGCTCCCTGCGCCG
GGTGGCTGAAATGGGAATTGCGTTTGTTTTCACCGACCGGCACGCCTATGTGCAAACCGCAGCGTATTATAACTCCCTTG
AGGACCTGGCGCAGGTGGATTGGAAGCTCCTGCAGTCCCGCGATTTCAGCAACGACCCGAACGACCCGGGCAAAAAGGAG
CGATACCAAGCCGAGGCCCTGGTGTATCGCCATCTACCCATGGCCGGCCTTATGAGTCTCGTTTGTCACAATCCGGAAGT
GGAAGCGTACTTGTGCCAGGAAGTGGCCCGGCGTAATTTGTCCTTGAAGATTGCAGTACGACCGCGCTGGTATTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219712 WP_002916312.1 NZ_CP084873:801070-801336 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219712 NZ_CP116615:3700388-3701458 [Fontisphaera persica]
ATGATTACCTTCCAACAAGGTAATTTGCTCGAAGCCGAGGTGGAAGCCCTGGTGAACACGGTCAACACCGTGGGCGTCAT
GGGCAAGGGGATTGCGCTCATGTTCAAGGAACGCTATCCGGAAAATTTTCGCGCCTACGCCCAGGCCTGCAAAGCCGGCA
AGGTGCGTCCGGGCCGAATGTTTGTCACTGCCACGGGCGAATTGACCGGCCCCCGATGGATCATCAATTTTCCCACCAAA
GAACACTGGCGCAATCCATCGCGATTGGAGTGGATTGCGGCCGGTTTGGAAGACCTGGTGCGCGTAATCCGCGAAAAGAA
CATCCGCTCCGTGGCCCTGCCCCCCCTCGGTTGTGGGCAGGGCGGCCTCGATTGGAACCAGGTGCGCCCCCTCATCGAAA
GCATTCTGGGACAGCTTTCGGAAGTGCAGGTCATCGCCTTTGAACCCACGGTCCAATACCAGAATGTCGCCAAGCATGGC
GGCGTGGCGCAGTTGACCGTGCCGCGGGCCTTGATGGCGGAAACCATCCGCCGCTATTGGGTCTTGGGCATTGAGTGCAC
GCTCCTGGAAATTCATAAATTGGCCTGGTTTCTCAGCCAGGCCATCCAGCGGCGAAACCTTCCCGATGTGCTGGACCTGC
GTTTTCAAGCCGATCGTTATGGCCCTTACTCCCATCGCTTGAATCACCTCCTGAACGCCCTGGACGGCAGTTATCTGCGC
GCGAATAAACGGGTGGCTGATTGCACCCCCTGCGACACCATCGCCTTTGCCGACGAGAAAGCGGAAACGGTGGCTCTCTT
CCTGCGCCGCACGGAAAGCCGCCCTTACCTGCCTGTCCTGGATGACGTGGACCAGTGGATTGACGGCTACCAATCACCCT
TGGGCATGGAATTGCTCGCCACGGTGCACTGGTTGCTGGTGCAAGAGCGTTGCGCGCCGGAAGTGCGCGCCCTGCGGGAA
GCGCTCGCTCGCTGGCCCGGCGGCAAGGATGCCGGCCTGCGCAAAAACCGCTTATTCCAAGACCACCACCTGGCTGCTGC
CATTGAGCGGCTGCGTCCCTTAATAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References