Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 801070..801727 | Replicon | chromosome |
Accession | NZ_CP084873 | ||
Organism | Klebsiella pneumoniae strain 03-9138-2 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | LGL99_RS03950 | Protein ID | WP_002916310.1 |
Coordinates | 801317..801727 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | LGL99_RS03945 | Protein ID | WP_002916312.1 |
Coordinates | 801070..801336 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LGL99_RS03920 (796278) | 796278..797711 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
LGL99_RS03925 (797830) | 797830..798558 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
LGL99_RS03930 (798608) | 798608..798919 | + | 312 | WP_004144734.1 | N(4)-acetylcytidine aminohydrolase | - |
LGL99_RS03935 (799083) | 799083..799742 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
LGL99_RS03940 (799841) | 799841..800824 | - | 984 | WP_002916313.1 | tRNA-modifying protein YgfZ | - |
LGL99_RS03945 (801070) | 801070..801336 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
LGL99_RS03950 (801317) | 801317..801727 | + | 411 | WP_002916310.1 | protein YgfX | Toxin |
LGL99_RS03955 (801734) | 801734..802255 | - | 522 | WP_002916308.1 | flavodoxin FldB | - |
LGL99_RS03960 (802356) | 802356..803252 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
LGL99_RS03965 (803275) | 803275..803988 | + | 714 | WP_004185548.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LGL99_RS03970 (803994) | 803994..805727 | + | 1734 | WP_004149758.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T219712 WP_002916310.1 NZ_CP084873:801317-801727 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T219712 NZ_CP116615:3699747-3700385 [Fontisphaera persica]
ATGAGTGCTCTAACTCCACAAAATGCGCTGATATTCCGCATTACTCACCTGGCTAATATTCCCTGGCTATTGGATCATGG
CCTGCATTGCCAAAGCGCCCCCCAACGAGACCCTCATTTCCATGCTCTCGGCAATCCGGAGTTGATTGCGCGCCGCCAGC
ACCGCCGCGTGCCCATTGCCCCCGGGGGCACTCTGGCCGATTACGTGCCGTTTTACTTCACGCCCTATTCCATCATGCTT
TACAATATCAAGACGGGTCATGGGGGAGTTCCCCACGTCGCCAACGAACAGATTGTTTTTCTGGTGAGCTCCCTGCGCCG
GGTGGCTGAAATGGGAATTGCGTTTGTTTTCACCGACCGGCACGCCTATGTGCAAACCGCAGCGTATTATAACTCCCTTG
AGGACCTGGCGCAGGTGGATTGGAAGCTCCTGCAGTCCCGCGATTTCAGCAACGACCCGAACGACCCGGGCAAAAAGGAG
CGATACCAAGCCGAGGCCCTGGTGTATCGCCATCTACCCATGGCCGGCCTTATGAGTCTCGTTTGTCACAATCCGGAAGT
GGAAGCGTACTTGTGCCAGGAAGTGGCCCGGCGTAATTTGTCCTTGAAGATTGCAGTACGACCGCGCTGGTATTTTTAA
ATGAGTGCTCTAACTCCACAAAATGCGCTGATATTCCGCATTACTCACCTGGCTAATATTCCCTGGCTATTGGATCATGG
CCTGCATTGCCAAAGCGCCCCCCAACGAGACCCTCATTTCCATGCTCTCGGCAATCCGGAGTTGATTGCGCGCCGCCAGC
ACCGCCGCGTGCCCATTGCCCCCGGGGGCACTCTGGCCGATTACGTGCCGTTTTACTTCACGCCCTATTCCATCATGCTT
TACAATATCAAGACGGGTCATGGGGGAGTTCCCCACGTCGCCAACGAACAGATTGTTTTTCTGGTGAGCTCCCTGCGCCG
GGTGGCTGAAATGGGAATTGCGTTTGTTTTCACCGACCGGCACGCCTATGTGCAAACCGCAGCGTATTATAACTCCCTTG
AGGACCTGGCGCAGGTGGATTGGAAGCTCCTGCAGTCCCGCGATTTCAGCAACGACCCGAACGACCCGGGCAAAAAGGAG
CGATACCAAGCCGAGGCCCTGGTGTATCGCCATCTACCCATGGCCGGCCTTATGAGTCTCGTTTGTCACAATCCGGAAGT
GGAAGCGTACTTGTGCCAGGAAGTGGCCCGGCGTAATTTGTCCTTGAAGATTGCAGTACGACCGCGCTGGTATTTTTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT219712 WP_002916312.1 NZ_CP084873:801070-801336 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT219712 NZ_CP116615:3700388-3701458 [Fontisphaera persica]
ATGATTACCTTCCAACAAGGTAATTTGCTCGAAGCCGAGGTGGAAGCCCTGGTGAACACGGTCAACACCGTGGGCGTCAT
GGGCAAGGGGATTGCGCTCATGTTCAAGGAACGCTATCCGGAAAATTTTCGCGCCTACGCCCAGGCCTGCAAAGCCGGCA
AGGTGCGTCCGGGCCGAATGTTTGTCACTGCCACGGGCGAATTGACCGGCCCCCGATGGATCATCAATTTTCCCACCAAA
GAACACTGGCGCAATCCATCGCGATTGGAGTGGATTGCGGCCGGTTTGGAAGACCTGGTGCGCGTAATCCGCGAAAAGAA
CATCCGCTCCGTGGCCCTGCCCCCCCTCGGTTGTGGGCAGGGCGGCCTCGATTGGAACCAGGTGCGCCCCCTCATCGAAA
GCATTCTGGGACAGCTTTCGGAAGTGCAGGTCATCGCCTTTGAACCCACGGTCCAATACCAGAATGTCGCCAAGCATGGC
GGCGTGGCGCAGTTGACCGTGCCGCGGGCCTTGATGGCGGAAACCATCCGCCGCTATTGGGTCTTGGGCATTGAGTGCAC
GCTCCTGGAAATTCATAAATTGGCCTGGTTTCTCAGCCAGGCCATCCAGCGGCGAAACCTTCCCGATGTGCTGGACCTGC
GTTTTCAAGCCGATCGTTATGGCCCTTACTCCCATCGCTTGAATCACCTCCTGAACGCCCTGGACGGCAGTTATCTGCGC
GCGAATAAACGGGTGGCTGATTGCACCCCCTGCGACACCATCGCCTTTGCCGACGAGAAAGCGGAAACGGTGGCTCTCTT
CCTGCGCCGCACGGAAAGCCGCCCTTACCTGCCTGTCCTGGATGACGTGGACCAGTGGATTGACGGCTACCAATCACCCT
TGGGCATGGAATTGCTCGCCACGGTGCACTGGTTGCTGGTGCAAGAGCGTTGCGCGCCGGAAGTGCGCGCCCTGCGGGAA
GCGCTCGCTCGCTGGCCCGGCGGCAAGGATGCCGGCCTGCGCAAAAACCGCTTATTCCAAGACCACCACCTGGCTGCTGC
CATTGAGCGGCTGCGTCCCTTAATAAATTAA
ATGATTACCTTCCAACAAGGTAATTTGCTCGAAGCCGAGGTGGAAGCCCTGGTGAACACGGTCAACACCGTGGGCGTCAT
GGGCAAGGGGATTGCGCTCATGTTCAAGGAACGCTATCCGGAAAATTTTCGCGCCTACGCCCAGGCCTGCAAAGCCGGCA
AGGTGCGTCCGGGCCGAATGTTTGTCACTGCCACGGGCGAATTGACCGGCCCCCGATGGATCATCAATTTTCCCACCAAA
GAACACTGGCGCAATCCATCGCGATTGGAGTGGATTGCGGCCGGTTTGGAAGACCTGGTGCGCGTAATCCGCGAAAAGAA
CATCCGCTCCGTGGCCCTGCCCCCCCTCGGTTGTGGGCAGGGCGGCCTCGATTGGAACCAGGTGCGCCCCCTCATCGAAA
GCATTCTGGGACAGCTTTCGGAAGTGCAGGTCATCGCCTTTGAACCCACGGTCCAATACCAGAATGTCGCCAAGCATGGC
GGCGTGGCGCAGTTGACCGTGCCGCGGGCCTTGATGGCGGAAACCATCCGCCGCTATTGGGTCTTGGGCATTGAGTGCAC
GCTCCTGGAAATTCATAAATTGGCCTGGTTTCTCAGCCAGGCCATCCAGCGGCGAAACCTTCCCGATGTGCTGGACCTGC
GTTTTCAAGCCGATCGTTATGGCCCTTACTCCCATCGCTTGAATCACCTCCTGAACGCCCTGGACGGCAGTTATCTGCGC
GCGAATAAACGGGTGGCTGATTGCACCCCCTGCGACACCATCGCCTTTGCCGACGAGAAAGCGGAAACGGTGGCTCTCTT
CCTGCGCCGCACGGAAAGCCGCCCTTACCTGCCTGTCCTGGATGACGTGGACCAGTGGATTGACGGCTACCAATCACCCT
TGGGCATGGAATTGCTCGCCACGGTGCACTGGTTGCTGGTGCAAGAGCGTTGCGCGCCGGAAGTGCGCGCCCTGCGGGAA
GCGCTCGCTCGCTGGCCCGGCGGCAAGGATGCCGGCCTGCGCAAAAACCGCTTATTCCAAGACCACCACCTGGCTGCTGC
CATTGAGCGGCTGCGTCCCTTAATAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |