Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 202438..203177 Replicon chromosome
Accession NZ_CP084873
Organism Klebsiella pneumoniae strain 03-9138-2

Toxin (Protein)


Gene name tacT Uniprot ID A0A4U9WP91
Locus tag LGL99_RS00990 Protein ID WP_004901283.1
Coordinates 202692..203177 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LGL99_RS00985 Protein ID WP_003026799.1
Coordinates 202438..202704 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL99_RS00970 (197942) 197942..200011 + 2070 WP_004901297.1 glycine--tRNA ligase subunit beta -
LGL99_RS00975 (200307) 200307..201676 + 1370 WP_087661561.1 IS3 family transposase -
LGL99_RS00980 (201877) 201877..202305 + 429 WP_004901287.1 GFA family protein -
LGL99_RS00985 (202438) 202438..202704 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LGL99_RS00990 (202692) 202692..203177 + 486 WP_004901283.1 GNAT family N-acetyltransferase Toxin
LGL99_RS00995 (203502) 203502..204548 - 1047 WP_022615678.1 IS481-like element ISKpn28 family transposase -
LGL99_RS01000 (204622) 204622..204774 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
LGL99_RS01005 (205076) 205076..206695 + 1620 WP_226618841.1 ATP-binding cassette domain-containing protein -
LGL99_RS01010 (206794) 206794..207006 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LGL99_RS01015 (207258) 207258..207548 - 291 WP_002921931.1 HTH-type transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 200951..204548 3597


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17594.32 Da        Isoelectric Point: 10.1788

>T219709 WP_004901283.1 NZ_CP084873:202692-203177 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLNQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T219709 NZ_CP116604:c2319215-2318958 [Streptococcus sp. HN38]
ATGGGAATTCATTTTACAGAGGATGCTTGGGAAGACTATCTTAATTGGCAGGGTCAGGATAAGAAAACACTGAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGAATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCGAGACGGATTGATGCGGAGAATCGGTTGATTTATATGGTAGAAGCAGACCAGTTGTATATCTTGTCGTTA
AAGGACCATTATGGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT219709 WP_003026799.1 NZ_CP084873:202438-202704 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT219709 NZ_CP116604:c2319477-2319217 [Streptococcus sp. HN38]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTACATGAAAAAGGTCAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCTGAGGAAGATATTGTTGTACTCTCAAAGAGCGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGC
AATCTGATAGAGGCAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9WP91

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References