Detailed information of TA system TA219707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4960669..4962350
• Replicon: chromosome
• Accession: NZ_CP084871
• Organism: Klebsiella pneumoniae strain 04A025

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LGM00_RS24140
• Protein ID: WP_004178299.1
• Coordinates: 4960669..4961586 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LGM00_RS24145
• Protein ID: WP_004177809.1
• Coordinates: 4961592..4962350 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGM00_RS24120 (4955975)	4955975..4957495	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LGM00_RS24125 (4957492)	4957492..4958490	+	999	WP_002885172.1	ribose ABC transporter permease	-
LGM00_RS24130 (4958521)	4958521..4959462	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LGM00_RS24135 (4959537)	4959537..4960544	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LGM00_RS24140 (4960669)	4960669..4961586	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGM00_RS24145 (4961592)	4961592..4962350	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LGM00_RS24150 (4962436)	4962436..4963164	-	729	WP_004178298.1	response regulator transcription factor	-
LGM00_RS24155 (4963437)	4963437..4965584	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LGM00_RS24160 (4965581)	4965581..4965724	-	144	WP_022631365.1	hypothetical protein	-
LGM00_RS24165 (4966162)	4966162..4966848	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T219707 WP_004178299.1 NZ_CP084871:c4961586-4960669 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T219707 NZ_CP116604:1682078-1682269 [Streptococcus sp. HN38]
ATGCCACTTACTGGAAAAGAAATGGCAAAACTTGCAGAGGCTAACGGGTGGAAAGAAATCCGAGTTAATGGAAGTCACCA
CCATTTCAAAAAAGAAGGATTTTCAAAAATAGTCACAATCCCAGTTCATGGAAACAAGGACTTGGGCAAAGGGCTAGAAA
AGAAAATCCTGAGAGATTTGGGGCTACTTTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT219707 WP_004177809.1 NZ_CP084871:c4962350-4961592 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT219707 NZ_CP116604:1682305-1682682 [Streptococcus sp. HN38]
ATGTTAAAATCTTACCCAGCTATTTTTCATAAAGATGAACAAGGTTATTGGGTGGAGTTCCCAGAGTTTAGTGGTGGTAC
TCAAGGGGATAACCTTGAGGAAGCTATGTACAATGCCCGTGATTTTTTAGAAAGCTCTATTGCCCTTTATATTGATGAGG
GGATGGAGTTACCAAAAGTAAGCGATATAAAGGAGTTAAGCGCTCCTGATGGCTTTGTTTCAATGATACAAGCTGATCCA
ACACCGTATATTAAGAATAATAAAGCAATTAGAAAGAATGTGACAGTGCCTGAATGGTTAACAAAATTGGCAGACCGTGA
GGGTTTGAACTATTCGGAAATTTTAACAACGGCTTTAGAAACACGATTACAAGTGTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05