Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4804975..4805491 Replicon chromosome
Accession NZ_CP084871
Organism Klebsiella pneumoniae strain 04A025

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LGM00_RS23350 Protein ID WP_004178374.1
Coordinates 4804975..4805259 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM00_RS23355 Protein ID WP_002886901.1
Coordinates 4805249..4805491 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM00_RS23325 (4800459) 4800459..4800722 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
LGM00_RS23330 (4800852) 4800852..4801025 + 174 WP_032408826.1 hypothetical protein -
LGM00_RS23335 (4801028) 4801028..4801771 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM00_RS23340 (4802128) 4802128..4804266 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM00_RS23345 (4804507) 4804507..4804971 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM00_RS23350 (4804975) 4804975..4805259 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM00_RS23355 (4805249) 4805249..4805491 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM00_RS23360 (4805569) 4805569..4807479 - 1911 WP_004178373.1 PRD domain-containing protein -
LGM00_RS23365 (4807502) 4807502..4808656 - 1155 WP_004178372.1 lactonase family protein -
LGM00_RS23370 (4808723) 4808723..4809463 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T219706 WP_004178374.1 NZ_CP084871:c4805259-4804975 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219706 NZ_CP116604:c1597309-1597127 [Streptococcus sp. HN38]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219706 WP_002886901.1 NZ_CP084871:c4805491-4805249 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219706 NZ_CP116604:c1597089-1596640 [Streptococcus sp. HN38]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATAAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAACTTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References