Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837440..838097 Replicon chromosome
Accession NZ_CP084871
Organism Klebsiella pneumoniae strain 04A025

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM00_RS04210 Protein ID WP_002916310.1
Coordinates 837687..838097 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM00_RS04205 Protein ID WP_002916312.1
Coordinates 837440..837706 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM00_RS04180 (832596) 832596..834029 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
LGM00_RS04185 (834148) 834148..834876 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM00_RS04190 (834926) 834926..835237 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM00_RS04195 (835401) 835401..836060 + 660 WP_002916317.1 hemolysin III family protein -
LGM00_RS04200 (836211) 836211..837194 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
LGM00_RS04205 (837440) 837440..837706 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM00_RS04210 (837687) 837687..838097 + 411 WP_002916310.1 protein YgfX Toxin
LGM00_RS04215 (838104) 838104..838625 - 522 WP_004144730.1 flavodoxin FldB -
LGM00_RS04220 (838726) 838726..839622 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM00_RS04225 (839645) 839645..840358 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM00_RS04230 (840364) 840364..842097 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219693 WP_002916310.1 NZ_CP084871:837687-838097 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219693 NZ_CP116581:1090673-1090930 [Enterococcus durans]
ATGATTAAGGCATGGTCTGATGACGCATGGAACGATTATCTTTATTGGTATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAATAAATTGATAAAAGACATTGATCGTTCCCCTTTTAATGGATTAGGAAAGCCTGAGCCGTTAAAGCACGATTTAT
CTGGGAAATGGTCAAGAAGAATTACAGATGAACACAGACTGATATATAGAGTTGAAAATGAAACGATATTTATCTATTCT
GCAAAAGACCATTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219693 WP_002916312.1 NZ_CP084871:837440-837706 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219693 NZ_CP116581:1090411-1090680 [Enterococcus durans]
ATGGAAGCAGTATCTTATTCAAACTTCCGAAAAAATTTGCGTGGTTATATGAAACAAGTAAATGAAGATGCTGAAACACT
TATCGTAACAAGTAAAGATGTTGATGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACATTGA
GAACACTTTCTAACAATTACGTGATGGAAAAAATTCGTAGAGGGGACGAACAGTTTTCAAAAGGTACATTTAAGAAACAT
GACTTAATTGAGGTCGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References