Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4920785..4921442 Replicon chromosome
Accession NZ_CP084870
Organism Klebsiella pneumoniae strain BJ1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM01_RS23395 Protein ID WP_002916310.1
Coordinates 4920785..4921195 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM01_RS23400 Protein ID WP_002916312.1
Coordinates 4921176..4921442 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM01_RS23375 (4916785) 4916785..4918518 - 1734 WP_032445465.1 single-stranded-DNA-specific exonuclease RecJ -
LGM01_RS23380 (4918524) 4918524..4919237 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM01_RS23385 (4919260) 4919260..4920156 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM01_RS23390 (4920257) 4920257..4920778 + 522 WP_004144730.1 flavodoxin FldB -
LGM01_RS23395 (4920785) 4920785..4921195 - 411 WP_002916310.1 protein YgfX Toxin
LGM01_RS23400 (4921176) 4921176..4921442 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM01_RS23405 (4921688) 4921688..4922671 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
LGM01_RS23410 (4922822) 4922822..4923481 - 660 WP_002916317.1 hemolysin III family protein -
LGM01_RS23415 (4923645) 4923645..4923956 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM01_RS23420 (4924006) 4924006..4924734 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM01_RS23425 (4924853) 4924853..4926286 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219690 WP_002916310.1 NZ_CP084870:c4921195-4920785 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219690 NZ_CP116579:c1811454-1811188 [Enterococcus durans]
GTGACCTATCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAATATCAAGCTACATTGATTGT
TCGATGGCTGTATCAACATATTGATGGCGTTGATGACCCGAGAAAATTCGGGAAAGGGTTGACAGCCAATCGTTCAGGGC
AATGGCGTTATCGGATTGGCAAATATCGAGTGTTGGTAGAAATAGAAGATAATCAAATGGTTGTCATTGCTATTCAAGTG
GGACACCGAAGAAATGTCTATGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219690 WP_002916312.1 NZ_CP084870:c4921442-4921176 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219690 NZ_CP116579:c1811681-1811451 [Enterococcus durans]
ATGGCTATGATTACGGTACGTGTGAGTGATGCTGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGAATTACTTT
ATCTGAACTATTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGATCGACAAACAGCTGAAATTGCCCATAAAC
ATTGGATAGAAAGTGGGAAGCCAACTGTATCCATGGAAGAAATACTGAATGAATTTGGAGGACTAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References