Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1728187..1728806 Replicon chromosome
Accession NZ_CP084870
Organism Klebsiella pneumoniae strain BJ1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM01_RS08300 Protein ID WP_002892050.1
Coordinates 1728187..1728405 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM01_RS08305 Protein ID WP_002892066.1
Coordinates 1728432..1728806 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM01_RS08265 (1724234) 1724234..1724497 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
LGM01_RS08270 (1724497) 1724497..1724637 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM01_RS08275 (1724634) 1724634..1725332 - 699 WP_002892021.1 GNAT family protein -
LGM01_RS08280 (1725433) 1725433..1726884 + 1452 WP_032445639.1 PLP-dependent aminotransferase family protein -
LGM01_RS08285 (1726859) 1726859..1727329 - 471 WP_002892026.1 YlaC family protein -
LGM01_RS08290 (1727350) 1727350..1727490 + 141 WP_004147370.1 hypothetical protein -
LGM01_RS08295 (1727462) 1727462..1728028 - 567 WP_002892030.1 maltose O-acetyltransferase -
LGM01_RS08300 (1728187) 1728187..1728405 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM01_RS08305 (1728432) 1728432..1728806 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM01_RS08310 (1729292) 1729292..1732438 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM01_RS08315 (1732461) 1732461..1733654 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219679 WP_002892050.1 NZ_CP084870:c1728405-1728187 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219679 NZ_CP116575:c2668382-2668239 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219679 WP_002892066.1 NZ_CP084870:c1728806-1728432 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219679 NZ_CP116575:2668119-2668306 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References