Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1004437..1004953 Replicon chromosome
Accession NZ_CP084870
Organism Klebsiella pneumoniae strain BJ1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LGM01_RS04875 Protein ID WP_032446557.1
Coordinates 1004669..1004953 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM01_RS04870 Protein ID WP_002886901.1
Coordinates 1004437..1004679 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM01_RS04855 (1000465) 1000465..1001205 + 741 WP_002886899.1 KDGP aldolase family protein -
LGM01_RS04860 (1001272) 1001272..1002426 + 1155 WP_002886900.1 lactonase family protein -
LGM01_RS04865 (1002449) 1002449..1004359 + 1911 WP_004152270.1 PRD domain-containing protein -
LGM01_RS04870 (1004437) 1004437..1004679 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM01_RS04875 (1004669) 1004669..1004953 + 285 WP_032446557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM01_RS04880 (1004957) 1004957..1005421 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM01_RS04885 (1005750) 1005750..1007888 - 2139 WP_032446556.1 anaerobic ribonucleoside-triphosphate reductase -
LGM01_RS04890 (1008245) 1008245..1008988 - 744 WP_032446555.1 MurR/RpiR family transcriptional regulator -
LGM01_RS04895 (1008991) 1008991..1009164 - 174 WP_002886906.1 hypothetical protein -
LGM01_RS04900 (1009249) 1009249..1009557 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11110.98 Da        Isoelectric Point: 10.3787

>T219677 WP_032446557.1 NZ_CP084870:1004669-1004953 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHLANKRL

Download         Length: 285 bp

>T219677 NZ_CP116575:633433-633561 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAGGCTCTATAATTTAAAGGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219677 WP_002886901.1 NZ_CP084870:1004437-1004679 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219677 NZ_CP116575:c633538-633460 [Enterococcus faecalis]
TATTTTTGTTGTCTAAGACAAGCGCTAAGATACCGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References