219669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4822420..4823077 Replicon chromosome
Accession NZ_CP084868
Organism Klebsiella pneumoniae strain SA1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM08_RS23195 Protein ID WP_002916310.1
Coordinates 4822420..4822830 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM08_RS23200 Protein ID WP_002916312.1
Coordinates 4822811..4823077 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM08_RS23175 (4818420) 4818420..4820153 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
LGM08_RS23180 (4820159) 4820159..4820872 - 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM08_RS23185 (4820895) 4820895..4821791 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM08_RS23190 (4821892) 4821892..4822413 + 522 WP_002916308.1 flavodoxin FldB -
LGM08_RS23195 (4822420) 4822420..4822830 - 411 WP_002916310.1 protein YgfX Toxin
LGM08_RS23200 (4822811) 4822811..4823077 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM08_RS23205 (4823323) 4823323..4824306 + 984 WP_022615657.1 tRNA-modifying protein YgfZ -
LGM08_RS23210 (4824457) 4824457..4825116 - 660 WP_002916317.1 hemolysin III family protein -
LGM08_RS23215 (4825280) 4825280..4825591 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM08_RS23220 (4825640) 4825640..4826368 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM08_RS23225 (4826487) 4826487..4827920 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219669 WP_002916310.1 NZ_CP084868:c4822830-4822420 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219669 NZ_CP116571:2827658-2827807 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219669 WP_002916312.1 NZ_CP084868:c4823077-4822811 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219669 NZ_CP116571:c2827924-2827740 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References