Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1574808..1575427 Replicon chromosome
Accession NZ_CP084868
Organism Klebsiella pneumoniae strain SA1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM08_RS07430 Protein ID WP_002892050.1
Coordinates 1574808..1575026 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM08_RS07435 Protein ID WP_002892066.1
Coordinates 1575053..1575427 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM08_RS07395 (1570855) 1570855..1571118 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
LGM08_RS07400 (1571118) 1571118..1571258 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM08_RS07405 (1571255) 1571255..1571953 - 699 WP_004177238.1 GNAT family protein -
LGM08_RS07410 (1572054) 1572054..1573505 + 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
LGM08_RS07415 (1573480) 1573480..1573950 - 471 WP_002892026.1 YlaC family protein -
LGM08_RS07420 (1573971) 1573971..1574111 + 141 WP_004147370.1 hypothetical protein -
LGM08_RS07425 (1574083) 1574083..1574649 - 567 WP_002892030.1 maltose O-acetyltransferase -
LGM08_RS07430 (1574808) 1574808..1575026 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM08_RS07435 (1575053) 1575053..1575427 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM08_RS07440 (1575913) 1575913..1579059 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM08_RS07445 (1579082) 1579082..1580275 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219658 WP_002892050.1 NZ_CP084868:c1575026-1574808 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219658 NZ_CP116569:2631257-2631400 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219658 WP_002892066.1 NZ_CP084868:c1575427-1575053 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219658 NZ_CP116569:c2631146-2631000 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References