219655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 851245..851761 Replicon chromosome
Accession NZ_CP084868
Organism Klebsiella pneumoniae strain SA1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LGM08_RS03995 Protein ID WP_004178374.1
Coordinates 851477..851761 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM08_RS03990 Protein ID WP_002886901.1
Coordinates 851245..851487 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM08_RS03975 (847273) 847273..848013 + 741 WP_004186692.1 KDGP aldolase family protein -
LGM08_RS03980 (848080) 848080..849234 + 1155 WP_004210635.1 lactonase family protein -
LGM08_RS03985 (849257) 849257..851167 + 1911 WP_004152270.1 PRD domain-containing protein -
LGM08_RS03990 (851245) 851245..851487 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM08_RS03995 (851477) 851477..851761 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM08_RS04000 (851765) 851765..852229 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM08_RS04005 (852471) 852471..854609 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM08_RS04010 (854966) 854966..855709 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM08_RS04015 (855712) 855712..855885 - 174 WP_004210630.1 hypothetical protein -
LGM08_RS04020 (856015) 856015..856278 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T219655 WP_004178374.1 NZ_CP084868:851477-851761 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219655 NZ_CP116569:c2552452-2552348 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219655 WP_002886901.1 NZ_CP084868:851245-851487 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219655 NZ_CP116569:2552228-2552415 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References