Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 102325..103235 | Replicon | plasmid pKp_SA12_1 |
| Accession | NZ_CP084867 | ||
| Organism | Klebsiella pneumoniae strain SA12 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | LGM09_RS26785 | Protein ID | WP_004026354.1 |
| Coordinates | 102325..102795 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | LGM09_RS26790 | Protein ID | WP_004026357.1 |
| Coordinates | 102792..103235 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGM09_RS26745 (LGM09_26745) | 97409..98011 | - | 603 | WP_011251277.1 | HAD domain-containing protein | - |
| LGM09_RS26750 (LGM09_26750) | 98014..98529 | - | 516 | WP_041937820.1 | hypothetical protein | - |
| LGM09_RS26755 (LGM09_26755) | 98637..99212 | - | 576 | WP_074424927.1 | hypothetical protein | - |
| LGM09_RS26760 (LGM09_26760) | 99329..100285 | - | 957 | WP_011251280.1 | DsbA family protein | - |
| LGM09_RS26765 (LGM09_26765) | 100345..100686 | - | 342 | WP_011251281.1 | hypothetical protein | - |
| LGM09_RS26770 (LGM09_26770) | 100700..101011 | - | 312 | WP_011251282.1 | hypothetical protein | - |
| LGM09_RS26775 (LGM09_26775) | 101028..101477 | - | 450 | WP_011251283.1 | thioredoxin fold domain-containing protein | - |
| LGM09_RS26785 (LGM09_26785) | 102325..102795 | - | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| LGM09_RS26790 (LGM09_26790) | 102792..103235 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| LGM09_RS26795 (LGM09_26795) | 103336..103839 | - | 504 | Protein_112 | DUF4113 domain-containing protein | - |
| LGM09_RS26800 (LGM09_26800) | 103937..104158 | - | 222 | WP_004213643.1 | DUF2188 domain-containing protein | - |
| LGM09_RS26805 (LGM09_26805) | 104339..104458 | - | 120 | Protein_114 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| LGM09_RS26810 (LGM09_26810) | 104533..106659 | - | 2127 | WP_004213640.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| LGM09_RS26815 (LGM09_26815) | 106746..107699 | - | 954 | Protein_116 | fec operon regulator FecR | - |
| LGM09_RS26820 (LGM09_26820) | 107696..108217 | - | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA | 1..230142 | 230142 | |
| - | flank | IS/Tn | - | - | 101479..101982 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T219651 WP_004026354.1 NZ_CP084867:c102795-102325 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
>T219651 NZ_CP116568:34900-35175 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCCCGAATAGGCTCACATAGTGAATTATTTCGATGA
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCCCGAATAGGCTCACATAGTGAATTATTTCGATGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT219651 WP_004026357.1 NZ_CP084867:c103235-102792 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT219651 NZ_CP116568:34641-34907 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |