Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4882941..4883457 Replicon chromosome
Accession NZ_CP084866
Organism Klebsiella pneumoniae strain SA12

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag LGM09_RS23625 Protein ID WP_004178374.1
Coordinates 4882941..4883225 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM09_RS23630 Protein ID WP_002886901.1
Coordinates 4883215..4883457 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM09_RS23600 (4878337) 4878337..4878600 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LGM09_RS23605 (4878730) 4878730..4878903 + 174 WP_041169004.1 hypothetical protein -
LGM09_RS23610 (4878906) 4878906..4879649 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM09_RS23615 (4880006) 4880006..4882144 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM09_RS23620 (4882473) 4882473..4882937 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM09_RS23625 (4882941) 4882941..4883225 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM09_RS23630 (4883215) 4883215..4883457 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM09_RS23635 (4883535) 4883535..4885445 - 1911 WP_012737231.1 PRD domain-containing protein -
LGM09_RS23640 (4885468) 4885468..4886622 - 1155 WP_012737230.1 lactonase family protein -
LGM09_RS23645 (4886689) 4886689..4887429 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T219648 WP_004178374.1 NZ_CP084866:c4883225-4882941 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219648 NZ_CP116566:2680528-2680650 [Enterococcus faecalis]
ATGAAAGGAGTAGGCCTTTTGTCAGCATATGAGACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGAT
TGCACTGATTGTGAAATTGCTTAAAGAAGACAAAAAGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219648 WP_002886901.1 NZ_CP084866:c4883457-4883215 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219648 NZ_CP116566:c2680845-2680583 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References