Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4131464..4132083 Replicon chromosome
Accession NZ_CP084866
Organism Klebsiella pneumoniae strain SA12

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM09_RS20055 Protein ID WP_002892050.1
Coordinates 4131865..4132083 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM09_RS20050 Protein ID WP_002892066.1
Coordinates 4131464..4131838 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM09_RS20040 (4126616) 4126616..4127809 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM09_RS20045 (4127832) 4127832..4130978 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM09_RS20050 (4131464) 4131464..4131838 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM09_RS20055 (4131865) 4131865..4132083 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM09_RS20060 (4132242) 4132242..4132808 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM09_RS20065 (4132780) 4132780..4132920 - 141 WP_004147370.1 hypothetical protein -
LGM09_RS20070 (4132941) 4132941..4133411 + 471 WP_002892026.1 YlaC family protein -
LGM09_RS20075 (4133386) 4133386..4134837 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
LGM09_RS20080 (4134938) 4134938..4135636 + 699 WP_002892021.1 GNAT family protein -
LGM09_RS20085 (4135633) 4135633..4135773 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM09_RS20090 (4135773) 4135773..4136036 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219646 WP_002892050.1 NZ_CP084866:4131865-4132083 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219646 NZ_CP116566:c2605118-2604975 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219646 WP_002892066.1 NZ_CP084866:4131464-4131838 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219646 NZ_CP116566:2604855-2605042 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References