Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795306..795963 Replicon chromosome
Accession NZ_CP084866
Organism Klebsiella pneumoniae strain SA12

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM09_RS03955 Protein ID WP_002916310.1
Coordinates 795553..795963 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM09_RS03950 Protein ID WP_002916312.1
Coordinates 795306..795572 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM09_RS03925 (790514) 790514..791947 - 1434 WP_226541550.1 6-phospho-beta-glucosidase -
LGM09_RS03930 (792066) 792066..792794 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM09_RS03935 (792844) 792844..793155 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM09_RS03940 (793319) 793319..793978 + 660 WP_002916317.1 hemolysin III family protein -
LGM09_RS03945 (794077) 794077..795060 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
LGM09_RS03950 (795306) 795306..795572 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM09_RS03955 (795553) 795553..795963 + 411 WP_002916310.1 protein YgfX Toxin
LGM09_RS03960 (795970) 795970..796491 - 522 WP_002916308.1 flavodoxin FldB -
LGM09_RS03965 (796592) 796592..797488 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM09_RS03970 (797511) 797511..798224 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM09_RS03975 (798230) 798230..799963 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219635 WP_002916310.1 NZ_CP084866:795553-795963 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219635 NZ_CP116564:c2655278-2655135 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219635 WP_002916312.1 NZ_CP084866:795306-795572 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219635 NZ_CP116564:2655015-2655202 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCATGT
TAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References