219630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5133695..5134320 Replicon chromosome
Accession NZ_CP084860
Organism Klebsiella pneumoniae strain SB1067

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LGM10_RS25200 Protein ID WP_002882817.1
Coordinates 5133695..5134078 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LGM10_RS25205 Protein ID WP_004150355.1
Coordinates 5134078..5134320 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM10_RS25185 (5131061) 5131061..5131963 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LGM10_RS25190 (5131960) 5131960..5132595 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LGM10_RS25195 (5132592) 5132592..5133521 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LGM10_RS25200 (5133695) 5133695..5134078 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LGM10_RS25205 (5134078) 5134078..5134320 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LGM10_RS25210 (5134525) 5134525..5135442 + 918 WP_023302328.1 alpha/beta hydrolase -
LGM10_RS25215 (5135456) 5135456..5136397 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LGM10_RS25220 (5136442) 5136442..5136879 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LGM10_RS25225 (5136876) 5136876..5137736 - 861 WP_004146232.1 virulence factor BrkB family protein -
LGM10_RS25230 (5137730) 5137730..5138329 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T219630 WP_002882817.1 NZ_CP084860:c5134078-5133695 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T219630 NZ_CP116564:c328314-328219 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT219630 WP_004150355.1 NZ_CP084860:c5134320-5134078 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT219630 NZ_CP116564:328120-328184 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References