Detailed information of TA system TA021963

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 4249758..4250554
• Replicon: chromosome
• Accession: NC_009052
• Organism: Shewanella baltica OS155

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8ECY2
• Locus tag: SBAL_RS18750
• Protein ID: WP_011847801.1
• Coordinates: 4249758..4250288 (-)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A3D8P1
• Locus tag: SBAL_RS18755
• Protein ID: WP_011847802.1
• Coordinates: 4250285..4250554 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL_RS18710	4245124..4245747	+	624	WP_011847796.1	hypothetical protein	-
SBAL_RS18715	4245744..4246133	+	390	WP_011847797.1	hypothetical protein	-
SBAL_RS18720	4246130..4246438	+	309	WP_011847798.1	hypothetical protein	-
SBAL_RS18725	4246439..4246717	+	279	WP_011847799.1	hypothetical protein	-
SBAL_RS18730	4246714..4246944	+	231	WP_011847800.1	hypothetical protein	-
SBAL_RS24720	4246941..4247078	+	138	WP_012586783.1	hypothetical protein	-
SBAL_RS18735	4247343..4247624	-	282	WP_012586781.1	hypothetical protein	-
SBAL_RS18740	4247886..4248827	-	942	WP_011845808.1	IS30-like element ISSba16 family transposase	-
SBAL_RS18745	4248887..4249411	-	525	WP_041410786.1	hypothetical protein	-
SBAL_RS18750	4249758..4250288	-	531	WP_011847801.1	GNAT family N-acetyltransferase	Toxin
SBAL_RS18755	4250285..4250554	-	270	WP_011847802.1	DUF1778 domain-containing protein	Antitoxin
SBAL_RS18760	4250764..4251393	-	630	WP_011847803.1	hypothetical protein	-
SBAL_RS18765	4251987..4252634	-	648	WP_049765984.1	hypothetical protein	-
SBAL_RS18770	4252817..4253302	-	486	WP_011847806.1	hypothetical protein	-
SBAL_RS18775	4253952..4254626	-	675	WP_011847807.1	Fe2+-dependent dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4211201..4254626	43425
	-	flank	IS/Tn	-	-	4247886..4248827	941

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (96-155)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 19727.98 Da
• Isoelectric Point: 8.6014

>T21963 WP_011847801.1 NC_009052:c4250288-4249758 [Shewanella baltica OS155]
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAVTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTGQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Nucleotide

• Length: 531 bp

>T21963 NC_009052:c4250288-4249758 [Shewanella baltica OS155]
GTGAGTTATTCCAAGACTTTTAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCGAAACACATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGTTACGC
CATTACCCAATCAAAAATATCCAATTTGCTCTTTCTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCCATGGGTAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCCGTCCATAAAGAGTTTCACGG
TAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATATCTTTGGGAAATTAACGCTCACATGCGAGCTTATGCCA
TTGTGGTCGATTGCTTAACTGGCCAAGCTGAATCATTTTACGCTAAGTATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTAAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9889.35 Da
• Isoelectric Point: 4.8949

>AT21963 WP_011847802.1 NC_009052:c4250554-4250285 [Shewanella baltica OS155]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAA
AFTKRGDFK

Nucleotide

• Length: 270 bp

>AT21963 NC_009052:c4250554-4250285 [Shewanella baltica OS155]
ATGGCAACTGCAAGACTTGATATCCGTTTGGATGAAGAGATCAAAGCTAAGGCTGAGAAAGCATCGGCTTTGCTCGGGTT
AAAAAGCTTAACTGAATACGTCGTTCGCTTAATGGACGAAGATTCAACTCAGGTGATTGCTGAGCACGAAAGCATTACTG
TTAAAGCTGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGCCCCGAACAAGGCATTGCGTGAAGCGGCT
GCATTTACTAAACGTGGTGACTTTAAGTGA

Structures

Toxin

• AlphaFold DB: A3D8P0

Antitoxin

• AlphaFold DB: A3D8P1