219628

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4621376..4621892 Replicon chromosome
Accession NZ_CP084860
Organism Klebsiella pneumoniae strain SB1067

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LGM10_RS22725 Protein ID WP_002886902.1
Coordinates 4621376..4621660 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LGM10_RS22730 Protein ID WP_002886901.1
Coordinates 4621650..4621892 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM10_RS22700 (4616792) 4616792..4617055 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
LGM10_RS22705 (4617185) 4617185..4617358 + 174 WP_032410138.1 hypothetical protein -
LGM10_RS22710 (4617361) 4617361..4618104 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
LGM10_RS22715 (4618461) 4618461..4620599 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM10_RS22720 (4620908) 4620908..4621372 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM10_RS22725 (4621376) 4621376..4621660 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM10_RS22730 (4621650) 4621650..4621892 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM10_RS22735 (4621970) 4621970..4623880 - 1911 WP_009486549.1 PRD domain-containing protein -
LGM10_RS22740 (4623903) 4623903..4625057 - 1155 WP_023302389.1 lactonase family protein -
LGM10_RS22745 (4625124) 4625124..4625864 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T219628 WP_002886902.1 NZ_CP084860:c4621660-4621376 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T219628 NZ_CP116563:34900-35175 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAATT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCATGCACTAACAGGAAATTATA
TAGGTACACGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCCCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT219628 WP_002886901.1 NZ_CP084860:c4621892-4621650 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219628 NZ_CP116563:34641-34907 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References