219625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3883557..3884176 Replicon chromosome
Accession NZ_CP084860
Organism Klebsiella pneumoniae strain SB1067

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LGM10_RS19165 Protein ID WP_002892050.1
Coordinates 3883958..3884176 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LGM10_RS19160 Protein ID WP_002892066.1
Coordinates 3883557..3883931 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM10_RS19150 (3878709) 3878709..3879902 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LGM10_RS19155 (3879925) 3879925..3883071 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LGM10_RS19160 (3883557) 3883557..3883931 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LGM10_RS19165 (3883958) 3883958..3884176 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LGM10_RS19170 (3884335) 3884335..3884901 + 567 WP_002892030.1 maltose O-acetyltransferase -
LGM10_RS19175 (3884873) 3884873..3885013 - 141 WP_004147370.1 hypothetical protein -
LGM10_RS19180 (3885034) 3885034..3885504 + 471 WP_002892026.1 YlaC family protein -
LGM10_RS19185 (3885479) 3885479..3886930 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
LGM10_RS19190 (3887031) 3887031..3887729 + 699 WP_002892021.1 GNAT family protein -
LGM10_RS19195 (3887726) 3887726..3887866 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LGM10_RS19200 (3887866) 3887866..3888129 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T219625 WP_002892050.1 NZ_CP084860:3883958-3884176 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T219625 NZ_CP116561:2729541-2729663 [Enterococcus faecalis]
ATGAAAGGAGTAGGCCTTTTGTCAGCATATGAGACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGAT
TGCACTGATTGTGAAATTGCTTAAAGAAGACAAAAAGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT219625 WP_002892066.1 NZ_CP084860:3883557-3883931 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT219625 NZ_CP116561:c2729858-2729596 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCGGGCATCTTTTATTGATGGTCTTTTTAGGGGCGTTGTGCTATAATGG
TAATGAGAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAACGGTGACAAAATTTTAAAGATTTTG
AAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTTTAAGCAATTTCACAATCAGTGCAAT
CAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References