219615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789028..789685 Replicon chromosome
Accession NZ_CP084860
Organism Klebsiella pneumoniae strain SB1067

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LGM10_RS03930 Protein ID WP_002916310.1
Coordinates 789275..789685 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LGM10_RS03925 Protein ID WP_002916312.1
Coordinates 789028..789294 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM10_RS03900 (784184) 784184..785617 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LGM10_RS03905 (785736) 785736..786464 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LGM10_RS03910 (786514) 786514..786825 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LGM10_RS03915 (786989) 786989..787648 + 660 WP_002916317.1 hemolysin III family protein -
LGM10_RS03920 (787799) 787799..788782 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
LGM10_RS03925 (789028) 789028..789294 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LGM10_RS03930 (789275) 789275..789685 + 411 WP_002916310.1 protein YgfX Toxin
LGM10_RS03935 (789692) 789692..790213 - 522 WP_004144730.1 flavodoxin FldB -
LGM10_RS03940 (790314) 790314..791210 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LGM10_RS03945 (791233) 791233..791946 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LGM10_RS03950 (791952) 791952..793685 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T219615 WP_002916310.1 NZ_CP084860:789275-789685 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T219615 NZ_CP116559:2658020-2658163 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT219615 WP_002916312.1 NZ_CP084860:789028-789294 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT219615 NZ_CP116559:c2658354-2658096 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTACTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References