Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5307325..5307950 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag LGM11_RS26045 Protein ID WP_004187928.1
Coordinates 5307325..5307708 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LGM11_RS26050 Protein ID WP_004150355.1
Coordinates 5307708..5307950 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS26030 (5304691) 5304691..5305593 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LGM11_RS26035 (5305590) 5305590..5306225 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LGM11_RS26040 (5306222) 5306222..5307151 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LGM11_RS26045 (5307325) 5307325..5307708 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
LGM11_RS26050 (5307708) 5307708..5307950 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LGM11_RS26055 (5308144) 5308144..5309061 + 918 WP_004187929.1 alpha/beta hydrolase -
LGM11_RS26060 (5309075) 5309075..5310016 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LGM11_RS26065 (5310061) 5310061..5310498 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LGM11_RS26070 (5310495) 5310495..5311355 - 861 WP_004146232.1 virulence factor BrkB family protein -
LGM11_RS26075 (5311349) 5311349..5311948 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T219612 WP_004187928.1 NZ_CP084859:c5307708-5307325 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T219612 NZ_CP116559:c2579423-2579319 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTTAAATT
GCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT219612 WP_004150355.1 NZ_CP084859:c5307950-5307708 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT219612 NZ_CP116559:2579199-2579386 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTAACAATCAGC
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References