Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4821027..4821543 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag LGM11_RS23730 Protein ID WP_004192395.1
Coordinates 4821027..4821311 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag LGM11_RS23735 Protein ID WP_004192397.1
Coordinates 4821301..4821543 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS23705 (4816444) 4816444..4816707 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LGM11_RS23710 (4816837) 4816837..4817010 + 174 WP_002886906.1 hypothetical protein -
LGM11_RS23715 (4817013) 4817013..4817756 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LGM11_RS23720 (4818113) 4818113..4820251 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LGM11_RS23725 (4820559) 4820559..4821023 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LGM11_RS23730 (4821027) 4821027..4821311 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM11_RS23735 (4821301) 4821301..4821543 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LGM11_RS23740 (4821621) 4821621..4823531 - 1911 WP_004152270.1 PRD domain-containing protein -
LGM11_RS23745 (4823554) 4823554..4824708 - 1155 WP_004178372.1 lactonase family protein -
LGM11_RS23750 (4824775) 4824775..4825515 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T219610 WP_004192395.1 NZ_CP084859:c4821311-4821027 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T219610 NZ_CP116559:c312605-312510 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGCTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT219610 WP_004192397.1 NZ_CP084859:c4821543-4821301 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT219610 NZ_CP116559:312411-312475 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References