Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4734719..4735389 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name ypjF Uniprot ID A0A483GLH7
Locus tag LGM11_RS23335 Protein ID WP_023301398.1
Coordinates 4734719..4735051 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A483GII7
Locus tag LGM11_RS23340 Protein ID WP_023301397.1
Coordinates 4735072..4735389 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS23310 (4729944) 4729944..4730616 + 673 Protein_4569 DUF4400 domain-containing protein -
LGM11_RS23315 (4730627) 4730627..4731511 + 885 WP_004192285.1 RES domain-containing protein -
LGM11_RS23320 (4731710) 4731710..4731898 - 189 Protein_4571 transposase -
LGM11_RS23325 (4731915) 4731915..4733026 - 1112 Protein_4572 IS3 family transposase -
LGM11_RS23330 (4733425) 4733425..4734285 - 861 WP_023301399.1 hypothetical protein -
LGM11_RS23335 (4734719) 4734719..4735051 - 333 WP_023301398.1 TA system toxin CbtA family protein Toxin
LGM11_RS23340 (4735072) 4735072..4735389 - 318 WP_023301397.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGM11_RS23345 (4735408) 4735408..4735629 - 222 WP_023301396.1 DUF987 domain-containing protein -
LGM11_RS23350 (4735638) 4735638..4736120 - 483 WP_023301395.1 RadC family protein -
LGM11_RS23355 (4736129) 4736129..4736587 - 459 WP_023301394.1 antirestriction protein -
LGM11_RS23360 (4736673) 4736673..4736909 - 237 WP_032446575.1 DUF905 domain-containing protein -
LGM11_RS23365 (4736987) 4736987..4737397 - 411 WP_023301393.1 hypothetical protein -
LGM11_RS23370 (4737464) 4737464..4737901 - 438 WP_023301392.1 hypothetical protein -
LGM11_RS23375 (4737943) 4737943..4738479 - 537 WP_023301391.1 DUF4339 domain-containing protein -
LGM11_RS23380 (4738505) 4738505..4739215 - 711 WP_023301390.1 DeoR family transcriptional regulator -
LGM11_RS23385 (4739424) 4739424..4740248 - 825 WP_023301389.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-101)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12610.65 Da        Isoelectric Point: 5.6692

>T219609 WP_023301398.1 NZ_CP084859:c4735051-4734719 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM

Download         Length: 333 bp

>T219609 NZ_CP116558:c50287-49946 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11785.37 Da        Isoelectric Point: 6.6277

>AT219609 WP_023301397.1 NZ_CP084859:c4735389-4735072 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR

Download         Length: 318 bp

>AT219609 NZ_CP116558:c50517-50287 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A483GII7

References